HER2+ Metastatic Breast Cancer: Is T-DXd + Pertuzumab the New First-Line Standard? - Drs. Neil Iyengar, Komal Jhaveri, & Igor Makhlin

For more than a decade, CLEOPATRA defined first-line therapy in HER2-positive metastatic breast cancer.Now, DESTINY-Breast09 is forcing a fundamental rethink.In this in-depth roundtable, Drs. Neil Iyengar, Komal Jhaveri, and Igor Makhlin examine:• The legacy — and limitations — of CLEOPATRA• DESTINY-Breast09’s unprecedented ~40-month PFS• When T-DXd + pertuzumab should move to the frontline• Patient selection, toxicity management, and ILD vigilance• Sequencing strategies after frontline ADCs• How maintenance paradigms may evolveA must-watch discussion on efficacy vs durability, escalation vs personalization, and what “best therapy first” truly means in 2025.#HER2Positive #BreastCancer #Oncology #DESTINYBreast09 #TDXd #AntibodyDrugConjugates #CLEOPATRA #MetastaticBreastCancer #MedicalOncology #PrecisionOncology #ASCO #ESMO–Thanks for watching!Our podcasts are also available on: • Spotify - https://spotf.fi/chm-podcast • Amazon Music - https://amazn.so/chm-podcast • Apple Podcast - https://podcasts.apple.com/us/podcast/community-health-media/id1837428248 • Castbox - https://castbox.fm/vh/6735434 • Goodpods - https://goodpods.com/profile/chm-111066 • iHeartRadio - https://iheart.com/podcast/291542082 • Pocket Casts - https://pca.st/3ncdh11o–Community Health Media (CHM) is your full service healthcare communications partner, combining our production expertise with targeted multi-channel campaigns. We connect companies and healthcare brands with key opinion leaders, patients, and consumers through compelling content and live experiences.We’re an integrated marketing company that produces world-class content and curated peer to peer live experiences.We specialize in: • Peer to peer interviews, panels & round-tables • Curated live events & conferences • Professional in-depth content & research updates • Interactive learning modules & webinars • Live & on-demand webcasts & podcastsLearn more about us here - https://communityhealth.media