Highlights From ISC 2026: Uncontrolled Hypertension Among Stroke Survivors, PFO Guidelines Updates, and Clinical Trial Participation Benefit

Drs. Saver and Sanossian discuss ISC 2026 data highlighting neurologists’ frequent inaction on markedly uncontrolled hypertension in high‑risk stroke patients and the need for specialists to “own” blood pressure management at every visit. They also review refinements in patent foramen ovale (PFO) risk stratification, including Pascal algorithm-defined “possible” PFO cases, and explore how a “clinical trial effect” may lower stroke risk through greater patient engagement.