HIV in 2025 - the latest science, global burden and future outlook

A conversation with Professor Andrew McMichael, Professor Tomáš Hanke, and Dr Fon Acho about current priorities in HIV treatment and prevention. In this episode of To Immunity and Beyond, we talk to HIV immunologist Professor Andrew McMichael, vaccinologist Professor Tomáš Hanke, and Dr Fon Acho, a Cameroonian doctor and Oxford MSc immunology graduate. We discuss the global burden of HIV, and the possibilities offered by current and future vaccines and treatments. We also explore challenges in research funding and the importance of community engagement in intervention uptake. Further reading: Chanda, Chama et al. ‘Safety and broad immunogenicity of HIVconsvX conserved mosaic candidate T-cell vaccines vectored by ChAdOx1 and MVA in HIV-CORE 006: a double-blind, randomised, placebo-controlled phase 1 trial in healthy adults living without HIV-1 in eastern and southern Africa’. The Lancet Microbe, Volume 6, Issue 6, 101041. https://doi.org/10.1016/j.lanmic.2024.101041 Haynes, Barton et al. ‘Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies.’ Nat Rev Immunol. 2023 Mar;23(3):142-158. https://doi.org/10.1038/s41577-022-00753-w