HOT TOPICS: The Neuro-ARC Study on Levetiracetam Dosing

In this episode of the NCS Podcast Hot Topics series, host Richard Choi, DO, FNCS, is joined by Melissa Dang, PharmD, BCCCP, neurocritical care pharmacist at MedStar Franklin Square Medical Center, to discuss the article "Levetiracetam Dosing Optimization in Neurocritical Care Population: Neuro-ARC Study", recently published in Neurocritical Care. Their conversation explores how augmented renal clearance may reduce levetiracetam exposure in neurocritical care patients and the implications for seizure management in clinical practice. Dr. Dang breaks down the study's pharmacokinetic modeling, highlights key dosing findings and reviews the patient factors most strongly associated with increased drug clearance. She also discusses the study's limitations and emphasizes the need for caution when applying its findings across broader clinical settings. The views expressed on the NCS Podcast are solely those of the hosts and guests and do not necessarily reflect the opinions or official positions of the Neurocritical Care Society.