Hello Roy here, I just wanted to let you know that you can listen to the Roy Green Show ad-free on Amazon Music included with Prime. PUT DROPS, TIP-OS, FIRST PITCHES, TICK-OS, WHEN THE GAME IS ON, YOU CALL THE SHOTS, PED TO BEATWAY.CA AND BEAT YOUR WAY, MUST BE NICK AND POSS, ONTERIAL AS WE KNOW IT AND A POST ANIBIOTIC APOCOLIPS. A WAR AGAINST THE ANIBIOTIC RESISTANT SUPERBOG IS BEING FOT BY AMONG OTHERS, SHON BRADY WHO'S A WILD CHILD CHILD CHEMISTS, AS I UNDERSTAND IT AND FINANCIALLY BACK BY BILL AND MOLINDA GATES. A FASINATING ARTICAL IN WIRED MAGAZINE, AND IT'S THE COVER STORY OF THE CURRENT ADITION.
AND THE HEADLINE IS THE BATTLE AGAINST GLOBAL HEALTHCARE. THE TIGL IS HOW DIRTH COULD SAY PHEMANITY FROM AN INFECTURES, APOCOLIPES. AND THE RIDDER, THE REPORTER IS PETER ODRAY SMITH. HE'S REPORTER BASED IN NEW YORK.
AND PETA IS AND BILL AND MOLINDA GATES GET INVOLVED AND THE STORY BECOMES JUST ONE THAT YOU CAN'T Put DOWN. I READ IT THREE TIMES. Great, thanks for paneling me on the show. So, how bad, how bad is the situation as far as antibiotics inability to keep evolving superbugs under control as we have for the last half century plus.
We've heard the dire warnings from the English Public Health Boss and the World Health Organization, how about you seeing it as being? Uh, right now it's not that bad. And I guess that's part of the problem is that people don't think about it on a daily basis, so it's sort of like a slow brewing crisis that if we don't do anything it can become a real problem but it's not like somebody pushes a button somebody pushes a button and uh... you know bomb is dropped it's more of like a a slow-growing crisis that if we don't do anything now it's going to be you know a real uh...
down-stating in the problem future now one of the numbers of ten million people will die because of this if it's not halter some ten million people die over the next twelve to fifteen years uh... because of the superbugs uh... overcoming antibiotics yeah i mean i thought that that's not seen in uh... you know some people say those are inflated and other people say that those are you know that's really what's going to happen if if we can't find you drug and also take care better care the ones we do have that many efforts on their many efforts underway to find our create drugs capable of subduing the so-called superbugs which have morphed from bacteria immune to attack by antibiotics and you found uh...
chemists shan brady who immediately seems unconventional to say the least so who is shan brady and how's he addressing the fight against superbugs the ashram brady uh... he's uh... fairly young kam up to work for the rock of all university here in uh... new york city and uh...
he was part of a group that uh... have time here the use of metagenomic sequencing which is basically looking at dn a in any environmental sample and he is essentially taking that dn a out of soil and then transferring it to a bacteria to go to the lab and then sort of producing new chemistry from those that dn a that he's that extracted from uh... soil so it's sort of i've heard it is going to start like a sci-fi approach i mean traditionally most of the antibiotics we have uh... came from dirt so it's not that he's looking in a new exceptional place it's just that the technology he's using is really represents like a hard break from the past and it really is a whole a whole new way of doing things and i think uh...
you know so a lot of people thought this is going to be very easy early on to take take dn a out of but within the soil and sort of like just give them to in the program lab but it has proven really difficult and shundra is like the one or one of the few people that have sort of persevered the longest and has worked hard to sort of make this a reality you were introduced into as a somebody who's running around central park with the shovel and some some plastic bags and he's putting dirt in the plastic bags and off he goes to analyze what he's got and in interest under the doesn't leave his lab all that often and you know this is sort of a a way for him to serve demonstrate like just just how certain that you know i mean you can basically go anywhere in the flowerpot in your office and you know chances are you're gonna find some some new chemistry that has not previously been identified in if you know you're doing as he certainly does and you can produce all this wonderful chemistry that uh... hopefully will treat you in the future so the new strains of antibiotics capable of subduing the superbugs are literally under our feet and now the challenges transferring them into a syringe or pill for and then also of course have to prove their effectiveness we're not talking about something that's going to take just a year or two there's a whole little lengthy multi-year maybe even longer than a decade process of from the the soil so these syringe certainly i mean i think i think one of the one of the sort of recognition that everybody's had is that the science isn't sort of the hard part and the science of difficult the science of sort of it's it's totally possible to find you drugs hard part is really like showing that they work in and all models first and then in humans and i can as you were saying it can take up to ten years and it costs a lot of money to do so and historically that the rates of failure have been uh... rather high so a lot of our students are sort of interested in taking on the risk of developing a drug that is not a fairly high chance of a failing before ever reaches the clinic so on comes the world's wealthiest man bill gates bill gates and the bill and will indicate foundation they enter the picture so i was so many that works for for the foundation uh... had sort of heard about chanda adi's work and he had a call and said after me he could find uh...
some some drugs that were similar that could treat so similar to drugs that are a good to be and uh... he he showed that he could uh... he had some possibilities like fairly quickly so uh... they set up a meeting in new yorkin uh...
with bill gates and i guess the two of them headed off and uh... you know within within a couple of months he had found a new company called load of therapeutics and really just trying to expedite the process of finding about it and then commercializing them so bill gates wrote the check for the uh... for the new company and he was among the the funders of the new company the rather uh... there was a uh...
accelerated which is a startup incubator uh... but also contribute funding and some of that that money comes from uh... pharmaceutical firms so uh... it wasn't just bill gates is uh...
pet project but uh... he was among the funders uh... of this project when you talk to someone you talk to Sean Brady and he's not talking scientifically just talking in terms of i can understand uh... what is he say about the danger that we're facing and what is he say about is project and what is he say about where we are in the process now that we've got the world health organization and others like the and of the uh...
the bingley's medical officer or running a post antibiotic apocalypse where does he say we are in the process of going from that danger to being able to again say we have a syringe for stuff but is going to control we were afraid might not be controlled but is he how does he describe where we are yeah i think that i think that i think that i have a conversation about this and i think the people talk about about it but it's very much a doom and gloom uh... scenario it seems uh... very very uh... you know potentially devastating to sort of like that we know it but i think some of the sort of the optimist and he sees the bright side and he's obviously persevered uh...
you know for a very long time during this thing that i think a lot of people doing the thing was possible so i think he's very much an optimist and he very much believes that i possibly find the drugs and also possible to you know turn them into drugs that you were i could using the next twenty years so uh... i think one of the one of the interesting things is that you know this isn't uh... about it doesn't get people's heart pumping quite the way that uh... new cancer drug to work you know there is a lot more funding for immunotherapies which can treat cancer but i think he he wants to find a new way to like inject some enthusiasm into this search and uh...
you know he has opened it up so that uh... people can donate so i'll say his lab and i think he really wants to like excite people from like school children and teachers and people that are kind of like him and and just sort of like get some new into the album into this injection into the album into the field now it's necessary and i'm looking at a photograph that's uh... included with your article and it looks like it's actually looks like it's a major chicken coop but what it is is uh... look like a repository for thousands of bags of dirt and uh...
there's a guy in lab sort of lab clothing walking through it all and uh... and and assessing what he's got hold on to come back and continue with you i just want to read you a little bit from uh... the independent newspaper in the uk and this was from uh... october of last year twelve october england's chief medical officer has warned of a post antibiotic apocalypse as she issued a call to action urging global leaders to address the growing threat of antibiotic resistance professor dame sally davis said that if antibiotics lose their effectiveness it will spell quote the end of modern medicine and quote without the drugs used to fight infections common medical intervention such as cesarean sections cancer treatments and hip replacements will become incredibly risky she said we're really facing if we don't take action now a dreadful post antibiotic apocalypse i don't want to say to my children i didn't do my best to protect them and their children and health experts have previously warned that resistance to antimicrobial drugs because a bigger threat to mankind then cancer if no action is taken as to make it that drug-resistant infections will kill ten million people a year by twenty fifty ten million people a year the world health organization is issuing similar concerns when we come back or talk more with peter on race smith you were the cover story for wired magazine how dirt could save humanity from an infectious apocalypse he was both sides of the story and chooses what's right over what's wrong great the course radio network the covers already in wired magazine is how dirt could save humanity from an infectious apocalypse and the peter on race myth is the writer is a reporter in new york city joining us on the right-wing choris radio network i come back to uh...
something about uh... uh... mister brady chon brady the chemist peter does he have a schedule of any kind i asked you where he is in the process from dirt to syringe but as you have a schedule of any kind uh... where it went you know that he wants to keep in order to be able to produce an antibiotic that is able to defeat super bugs for specific uh...
bacterial illness like tuberculosis yeah i have a number of uh... candidate drugs drug that seem likely to treat uh... infections at least in the lab and i know that he is just begun some uh... animal experiments one of them uh...
treats mercy which is a resistant form of uh... staff infections uh... so i mean i again i think he's sort of in i i i i i i i i i i i i i i i i i i i i i a colleague sort of described him as being impatient and i think that uh... that's a fair characterization but again it's really hard to know exactly how long these things are going to take it in his colleagues saying i don't think in patients is a bad thing i mean obviously we want these things as fast as as possible and i know regulatory agencies have sort of allowed for an expedited timeline for approval of these drugs so i think once once he had once he's far along with uh...
one of these candidates uh... i think we might see these these drugs enter the clinic in a rather uh... quick quick manner this is no question that they are needed to read for a quote from your from your article antibiotics used to treat the deadliest pathogens are kept as a last resort when all else fails such as the i'd pronounce this kind of penance you can just call them c re okay yeah uh... gravely ill patients taking last line antibiotics can end up dead or they can end up cured either way they're not repeat customers which overall long term adds up to a negligible or negative return on investment waiting until the market for these life-saving antibiotics reaches critical mass for profitability is a recipe for catastrophe so this brings us into the into the issue of making money uh...
and the objective for pharmaceutical firms is obviously to be profitable which many of them are where does the profit factor fit into this this whole picture of how dirt could save humanity from an infectious apocalypse yeah i think that the the return on investment is sort of met mismatched with the societal and that the medical value of these drugs have so i think that a lot of people are trying to think of new incentives obviously people like the bill and the gate foundation are trying to support this as a stone traffic endeavor and i think i think uh... more recently uh... pharmaceutical firms uh... have you know sorry to express interest again in the antibiotic antimicrobial sector i mean i think as i was a reporting the story you know i think people and within the last year and even with the last six months people have been saying that our school firms are sort of coming around to the idea that uh...
petit even if there is an enemy to be made perhaps there is like some value in in finding these drugs and marketing them as as um... you know sort of a philanthropic yeah yeah peters are actually joining us uh... fascinating it's a great article peter on race with how to save humanity from an infectious apocalypse in white magazine will talk again thanks peter yet it's apparently it's a great show on the course radio network and when we come back they are back catharines with working canadians dot c a michael simpson former liberal member of parliament and the other day of form of money editor for the tron sun now vice president of kamri candidate as a major talk to the beauties about stick around a safer ontario means more police and prosecutors making sure my car doesn't get stolen it means building new jails the key criminals behind bars and it means there's no need to worry when i play at the park making every corner of the area safer to make all of our territory that's how we protect Ontario for all of us learn how to carry out that the c-a-slash safer Ontario paid for by the government of Ontario