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EPISODE · Nov 22, 2025 · 12 MIN

How Chronic Stress Rewrites Your Brain And How Mindset Rebuilds It

from The Longevity Podcast: Optimizing HealthSpan & MindSpan · host Dung Trinh

Send us Fan MailWe trace how chronic stress reshapes the amygdala, prefrontal cortex, and hippocampus, then show how mindset can flip your chemistry from destructive to regenerative within minutes. We share three practical tools to reframe stress, ground your attention, and recover on purpose.• difference between acute and chronic stress • enlargement of the amygdala and hypervigilance • dendritic retraction in the prefrontal cortex • suppressed neurogenesis in the hippocampus • mindset as a biological lever for DHEA and BDNF • evidence from Kelly McGonigal on stress beliefs • three tools: cognitive reframing, one-minute grounding, recovery cue • practical self-talk that redirects arousal toward performance • closing the stress loop to restore cognitive flexibilityThis podcast is created by Ai for educational and entertainment purposes only and does not constitute professional medical or health advice. Please talk to your healthcare team for medical advice. Never miss an episode—subscribe on your favorite podcast app!

Episode metadata supplied by the publisher feed · Published Nov 22, 2025

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Send us Fan Mail We trace how chronic stress reshapes the amygdala, prefrontal cortex, and hippocampus, then show how mindset can flip your chemistry from destructive to regenerative within minutes. We share three practical tools to reframe stress, ground your attention, and recover on purpose. • difference between acute and chronic stress • enlargement of the amygdala and hypervigilance • dendritic retraction in the prefrontal cortex • suppressed neurogenesis in the hippoc...

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How Chronic Stress Rewrites Your Brain And How Mindset Rebuilds It

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This episode was published on November 22, 2025.

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