How DeFi lending actually works (with Paul Frambot, cofounder and CEO of Morpho Labs) episode artwork

EPISODE · Apr 8, 2026 · 18 MIN

How DeFi lending actually works (with Paul Frambot, cofounder and CEO of Morpho Labs)

from a16z crypto show · host Andreessen Horowitz

What if the future of lending doesn’t need banks at all? Paul Frambot, cofounder and CEO of Morpho, explains what it means to build lending infrastructure without banks, and why DeFi’s real breakthrough isn’t “risk-free” loans, but open, onchain markets that make lending more transparent, competitive, and efficient. In this conversation, Paul breaks down the biggest misconception in DeFi lending, how to think about risk onchain, why institutions are learning faster than expected, and where banks, asset managers, fintechs, and stablecoins fit into the next wave of adoption. He also shares his long-term vision for finance: a world where open blockchain infrastructure replaces siloed financial systems, access to capital gets broader, and financial products become cheaper, more personalized, and easier to build. Highlights:  0:00 Intro  0:36 What Morpho actually does  1:22 DeFi’s biggest misconception  5:26 Why Wall Street is paying attention now  6:46 Who’s adopting onchain finance first: Banks or asset managers?  9:57 The race for a Euro stablecoin  10:49 The future of finance, 5–10 years out  11:16 Why finance is still broken  13:30 What open mortgage and credit markets could become on open blockchains  15:14 The worst advice Paul's received as a founder  17:17 What's wrong with an $8 croissant (besides the obvious) Follow a16z crypto for more...  X: https://x.com/a16zcrypto  LinkedIn: https://www.linkedin.com/showcase/a16zcrypto/posts/  YouTube: https://www.youtube.com/@a16zcrypto  Substack: https://a16zcrypto.substack.com/subscribe/   *** As always, none of the following should be taken as investment, business, legal, or tax advice. Please see a16z.com/disclosures for more important information, including a link to a list of our investments. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

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Morpho cofounder and CEO Paul Frambot joins us to discuss how onchain lending could change the future of finance. He explains what Morpho does, the biggest misconception in DeFi lending, why institutions are starting to pay attention, and how open blockchain infrastructure could make lending markets more transparent, competitive, and efficient. Paul also shares his longer-term view of a financial system with broader access to capital and more customizable financial products.

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How DeFi lending actually works (with Paul Frambot, cofounder and CEO of Morpho Labs)

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