How Dr. Jeannie Callum Helped Bring TXA to Ontario Paramedics | Prehospital Trauma Breakthrough

Dr. Jeannie Callum: The Architect of Prehospital TXA in OntarioWhat does it take to change an entire province’s approach to trauma care? For Dr. Jeannie Callum—hematologist, transfusion medicine specialist, and researcher—it took relentless advocacy, bold data, and a vision for saving lives before patients even reach the hospital. Known internationally for her expertise in bleeding disorders and transfusion science, Dr. Callum played a pivotal role in bringing tranexamic acid (TXA) out of the hospital and into the hands of Ontario paramedics.About Dr. Callum:https://research.sunnybrook.ca/researchers/jeannie-callum/https://pathology.queensu.ca/faculty-staff/jeannie-callumhttps://www.researchgate.net/profile/Jeannie-Callumhttps://www.youtube.com/watch?v=paAvUuXDChU&t=962s Join us as we delve into the critical topic of TXA in trauma treatment with one of the leading specialists in the field. Our guest, a renowned hematologist and transfusion medicine expert, shares her journey, expertise, and the importance of TXA in improving patient outcomes. Discover the intricacies of traumatic coagulopathy, the significance of timely TXA administration, and its application from pre-hospital to in-hospital settings. Chapters:00:00 Introduction to TXA and Trauma00:26 Expert Background and Journey02:58 The Importance of Early TXA Administration07:36 Mechanism and Benefits of TXA11:43 Addressing Concerns and Misconceptions16:53 Pre-Hospital and In-Hospital TXA Protocols25:33 Pediatric Considerations and Future Research30:00 Conclusion and Final ThoughtsReferences:Ontario Transfusion Quality Improvement Plan.Massive Hemorrhage Protocol Toolkit – Version 1 (October 2021).Available at: https://transfusionontario.org/wp-content/uploads/2021/10/MHP_Toolkit_v1_Oct2021.pdfCallum JL, Karkouti K, Lin Y, et al.The Pragmatic, Randomized Optimal Platelet and Plasma Ratios (PROPPR) Trial. JAMA Surg. 2020;155(9):e202243.Available at: https://jamanetwork.com/journals/jamasurgery/fullarticle/2771225Gayet-Ageron A, Prieto-Merino D, Ker K, et al.Effect of treatment delay on the effectiveness and safety of antifibrinolytics in acute severe haemorrhage: A meta-analysis. Lancet. 2023;401(10378):1344-1353.Available at: https://pubmed.ncbi.nlm.nih.gov/32897344/Yee DA, Knudson MM, Cohen MJ, et al.Prehospital tranexamic acid is associated with improved survival in severely injured patients with major hemorrhage. J Trauma Acute Care Surg. 2023 Nov;95(5):665–671.Available at: https://pubmed.ncbi.nlm.nih.gov/37928456/Roberts I, Shakur H, Coats T, et al.The CRASH-2 trial: A randomized controlled trial and economic evaluation of the effect of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients. Health Technol Assess. 2013;17(10):1–79.Available at: https://pubmed.ncbi.nlm.nih.gov/23477634/CRASH-3 trial collaborators.Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH-3): A randomized, placebo-controlled trial. Lancet. 2019;394(10210):1713–1723.Available at: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)32233-0/fulltextShariff ZA, Joshi N, Reardon PM, et al.Implementation of prehospital tranexamic acid (TXA) in Ontario: A provincial, prospective, collaborative approach. BMC Emerg Med. 2024;24(1):14.Available at: https://bmcemergmed.biomedcentral.com/articles/10.1186/s12873-024-01119-2Sperry JL, Guyette FX, Rosario-Rivera BL, et al.Early Cold Stored Platelet Transfusion Following Severe Injury: A Randomized Clinical Trial. Ann Surg. 2024 Aug 1;280(2):212-221.Available at: https://pubmed.ncbi.nlm.nih.gov/38708880/Relke N, Chornenki NLJ, Sholzberg M.Tranexamic acid evidence and controversies: An illustrated review. Res Pract Thromb Haemost. 2021;5(5):e12546.Available at: https://pubmed.ncbi.nlm.nih.gov/34278187/