How loneliness and purpose determine your wellbeing | Leo Pruimboom | #011 Master Change

“Genes don’t control your life – your life controls your genes,” says Dr. Leo Pruimboom in the eleventh episode of Mastering Change. A clinical psychoneuroimmunologist, researcher and pioneer in systems-based medicine, Dr. Pruimboom is challenging everything we think we know about trauma, disease, genes, psychology and mental health. “You can take a human being out of nature, but you can’t take nature out of the human being.”  Dr. Pruimboom makes a compelling case for the role of environment, connection, and behavioural agency in reversing modern illness. As he explains, we’re currently living in – and desperately trying to adapt to – a world we’re not made for. But thankfully, we have the capability to adapt: he reports the research showing that 120mins in nature per week can down regulate our blood pressure. We discussWhy most autoimmune diseases are misnamed (and aren’t autoimmune diseases at all) How loneliness rewires our organs The power of purpose – and how purpose of life intervention can shrink tumour size by 50%  That genes do nothing on their own: it’s our environment or choice that activate or silence them The importance of spontaneous neural activity – and how doing nothing is medicine Moment of Care: This episode discusses sensitive episodes related to trauma, mental health and potential distressing experiences. If you feel triggered at any point, please take a moment to check in with yourself and seek support. Watch this episode on Youtube: https://tinyurl.com/masteringchangepodcastFollow us on instagram: www.instagram.com/masterseventsltdVisit mastersevents.com/oxford-2026 for more details.