How Might Stress Trigger Migraine Pain?

Scientists are learning how stress may trigger a series of brain responses that could be linked to migraine, at least in mice. Molly O'Brien has more in this Migraine Minute News Update. Source: PACAP38/mast-cell-specific receptor axis mediates repetitive stress-induced headache in mice Script: A study published in the Journal of Headache and Pain explains how stress can lead to migraine pain. Research in mice found that stress increases a brain chemical called PACAP-38. This chemical activates specific cells that release inflammatory substances. This series of events can affect the trigeminovascular system, which may trigger migraine pain. The study's author notes that blocking or interrupting this pathway could offer a new way to treat or prevent migraine attacks.