How Overeating Rewires Our Brains – Neuroscience of Weight Gain & Loss | Nick Sterling, MD, PhD #4

In this episode, we discuss how overeating can lead to inflammation and neuron dysfunction in specific parts of the brain that control appetite and energy regulation. We review the neuroscience of appetite regulation, energy expenditure, and body fat regulation. Topics include hypothalamic dysfunction of body fat regulation, leptin resistance, neuro-inflammation, and physical changes in the hypothalamus involving microglia (the immune cells of the brain). We also review what is known about avoiding and reversing these changes. Chapters: 00:00:00 - Introduction 00:00:37 - Brain Changes in Obesity 00:01:20 - Leptin Deficiency & Obesity 00:03:25 - Leptin Replacement 00:04:43 - Hypothalamic Obesity 00:05:42 - What is the Hypothalamus? 00:06:51 - Food Intake, Appetite, & VMH 00:08:50 - Ob Gene 00:09:34 - The Satiety Factor 00:11:11 - Leptin Paradox 00:11:51 - Leptin Resistance 00:13:41 - Leptin Physiology 00:15:03 - Leptin Resistance 00:18:11 - Effects of Leptin Resistance 00:18:29 - Improving Leptin Resistance 00:20:24 - Hypothalamic Inflammation 00:24:08 - Triggers of Hypothalamic Inflammation 00:25:45 - Fatty Acids & Hypothalamic Inflammation 00:26:24 - Advanced Glycation End Products (AGEs) 00:27:05 - Current Knowledge on Hypothalamic Inflammation 00:28:17 - Summary 00:30:16 - Outro Social & Website: Instagram - https://www.instagram.com/sterlingmdphd  Twitter - https://twitter.com/sterlingmdphd Facebook - https://www.facebook.com/sterlingmdphd TikTok - https://www.tiktok.com/@sterlingmdphd Newsletter - http://eepurl.com/hQpdqT Subscribe to the Podcast: Apple Podcasts: https://apple.co/3y438C9 Spotify: https://open.spotify.com/show/5TDUK3F2sJXfnG63hSxJhT?si=40bb52e5b53f404c Google Podcasts: https://bit.ly/3Olanei References & Show Notes: http://www.nicksterling.com/