How to Have Sex While On Antidepressants episode artwork

EPISODE · Mar 3, 2026 · 40 MIN

How to Have Sex While On Antidepressants

from Sex With Emily · host Dr. Emily Morse

If you're on antidepressants and your sex drive has completely disappeared, I want you to know that you're not broken, and you don't have to choose between feeling mentally well and having a fulfilling sex life. SSRIs like Lexapro, Zoloft, and Prozac are genuinely life-changing for so many people, but nobody warns you that they can tank your desire, make orgasms nearly impossible, and quietly wreck your relationship in the process. In this episode, I'm breaking down exactly why this happens, and more importantly, what you can actually do about it. From simple timing hacks to alternative treatments that are showing real promise. In this episode, you'll learn: • Why SSRIs suppress desire and arousal on a hormonal level — and the one hack that can reduce side effects as soon as tonight • How to rebuild your sex drive when both you and your partner are medicated (yes, this is more common than you think) • The alternative treatments — TMS therapy, ketamine, and psilocybin — that are helping people get off antidepressants entirely More Dr. Emily:  • Shop With Emily! Explore Emily’s favorite toys, pleasure accessories, bedroom essentials, and more — designed to support your pleasure and confidence. Free shipping on orders $99+ (some exclusions apply). • Join the SmartSX Membership: Access exclusive sex coaching, live expert sessions, community building, and tools to enhance your pleasure and relationships with Dr. Emily Morse. • Interested in 1:1 Coaching with Emily? Go to sexwithemily.com/coaching to apply!  • Sex With Emily Guides: Explore pleasure, deepen connections, and enhance intimacy using these Sex With Emily downloadable guides. • The only sex book you’ll ever need: Smart Sex: How to Boost Your Sex IQ and Own Your Pleasure • Want more? Visit the Sex With Emily Website • Let’s get social: Instagram | X | Facebook | TikTok | Threads | YouTube • Let’s text: Sign up here • Want me to slide into your email inbox? Sign Up Here for sex tips on the regular. Chapters: 0:00 - Intro 0:31 - Sarah's Story: The SSRI Sex Drive Dilemma 3:50 - Why SSRIs Kill Your Libido (The Science) 6:50 - How Common Is This? Depression & Sex Stats 14:00 - Side Effects Breakdown: Vulva vs. Penis Owners 15:50 - Practical Hacks: Timing, Alcohol & Cannabis 20:53 - Alternative Treatments: TMS, Ketamine & Psychedelics 25:31 - Both Partners on SSRIs? How to Rebuild Intimacy 31:58 - The 36 Questions Study That Reignites Closeness 33:37 - Perimenopause, Hormones & Anti-Depressants at 48 Learn more about your ad choices. Visit megaphone.fm/adchoices

If you're on antidepressants and your sex drive has completely disappeared, I want you to know that you're not broken, and you don't have to choose between feeling mentally well and having a fulfilling sex life. SSRIs like Lexapro, Zoloft, and Prozac are genuinely life-changing for so many people, but nobody warns you that they can tank your desire, make orgasms nearly impossible, and quietly wreck your relationship in the process. In this episode, I'm breaking down exactly why this happens, and more importantly, what you can actually do about it. From simple timing hacks to alternative treatments that are showing real promise. In this episode, you'll learn: • Why SSRIs suppress desire and arousal on a hormonal level — and the one hack that can reduce side effects as soon as tonight • How to rebuild your sex drive when both you and your partner are medicated (yes, this is more common than you think) • The alternative treatments — TMS therapy, ketamine, and psilocybin — that are helping people get off antidepressants entirely More Dr. Emily:  • Shop With Emily! Explore Emily’s favorite toys, pleasure accessories, bedroom essentials, and more — designed to support your pleasure and confidence. Free shipping on orders $99+ (some exclusions apply). • Join the SmartSX Membership: Access exclusive sex coaching, live expert sessions, community building, and tools to enhance your pleasure and relationships with Dr. Emily Morse. • Interested in 1:1 Coaching with Emily? Go to sexwithemily.com/coaching to apply!  • Sex With Emily Guides: Explore pleasure, deepen connections, and enhance intimacy using these Sex With Emily downloadable guides. • The only sex book you’ll ever need: Smart Sex: How to Boost Your Sex IQ and Own Your Pleasure • Want more? Visit the Sex With Emily Website • Let’s get social: Instagram | X | Facebook | TikTok | Threads | YouTube • Let’s text: Sign up here • Want me to slide into your email inbox? Sign Up Here for sex tips on the regular. Chapters: 0:00 - Intro 0:31 - Sarah's Story: The SSRI Sex Drive Dilemma 3:50 - Why SSRIs Kill Your Libido (The Science) 6:50 - How Common Is This? Depression & Sex Stats 14:00 - Side Effects Breakdown: Vulva vs. Penis Owners 15:50 - Practical Hacks: Timing, Alcohol & Cannabis 20:53 - Alternative Treatments: TMS, Ketamine & Psychedelics 25:31 - Both Partners on SSRIs? How to Rebuild Intimacy 31:58 - The 36 Questions Study That Reignites Closeness 33:37 - Perimenopause, Hormones & Anti-Depressants at 48 Learn more about your ad choices. Visit megaphone.fm/adchoices

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How to Have Sex While On Antidepressants

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How long is this episode of Sex With Emily?

This episode is 40 minutes long.

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This episode was published on March 3, 2026.

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If you're on antidepressants and your sex drive has completely disappeared, I want you to know that you're not broken, and you don't have to choose between feeling mentally well and having a fulfilling sex life. SSRIs like Lexapro, Zoloft, and...

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