How to Treat Cancer of Unknown Primary (CUP) Origin – Drs. Harry Fuentes & Thor Halfdanarson episode artwork

EPISODE · Apr 6, 2026 · 21 MIN

How to Treat Cancer of Unknown Primary (CUP) Origin – Drs. Harry Fuentes & Thor Halfdanarson

from Oncology Brothers: Practice-Changing Cancer Discussions · host Oncology Brothers

In this episode of the Oncology Brothers podcast, we dived deep into the complexities of Cancer of Unknown Primary (CUP). Joined by Dr. Harry Fuentes Bayne and Dr. Thor Halfdanarson from the Mayo Clinic, they discussed the current standard of care, diagnostic workup, and treatment options for this challenging condition.   Key topics included: Initial diagnostic approaches for CUP, including imaging and tissue sampling The role of immunohistochemistry (IHC) and tumor markers in guiding treatment The use of next-generation sequencing (NGS) and tools like Cancer Type ID Treatment strategies, including chemotherapy regimens and the potential for immunotherapy The importance of thorough workup and palliative care in managing CUP Whether you're a healthcare professional or simply interested in oncology, this episode provides valuable insights into the latest approaches for diagnosing and treating cancer of unknown primary origin.   Listen us on: Spotify: https://open.spotify.com/show/31BXhY9FM4gPWG10WgE11o  Follow us on social media: ⁠X/Twitter: https://twitter.com/oncbrothers Instagram: https://www.instagram.com/oncbrothers Website: https://oncbrothers.com/    Don't forget to like, subscribe, and check out our other episodes for more discussions on treatment algorithms, conference highlights, and FDA approvals. Join us on this journey through the world of oncology! #CancerOfUnknownPrimary, #CUP, #NGS, #Immunohistochemistry, #OncologyBrothers

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This episode was published on April 6, 2026.

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