Immune checkpoint inhibitor endocrinopathies

This podcast episode covers the clinical landscape of immune checkpoint inhibitor induced endocrinopathies, focusing on mechanisms, diagnostic pathways, and long-term management strategies for practicing endocrinologists. Listeners will review the presentation of anti-CTLA-four induced hypophysitis, including its classic biphasic manifestation of pituitary swelling followed by central axes deficiencies. The episode contrasts this with the destructive, painless thyroiditis typically triggered by anti-PD-one and anti-PD-L-one agents, detailing the hyperacute shift from transient thyrotoxicosis to permanent hypothyroidism. Finally, the discussion addresses rapid beta-cell destruction leading to fulminant insulin-dependent diabetes, alongside rare toxicities like primary adrenalitis and hypoparathyroidism, emphasizing mandatory pre-cycle surveillance protocols.