Improving Flu Vaccine Effectiveness Through Clinical Research and Adjuvants

In this episode, we explore the role of adjuvants in vaccines. These addatives help the immune response to a vaccine, making it more effective at stoping infection, complication, hospitalization, and or death. We discuss the need for better vaccines and how adjuvants may be able to help.References:Grohskopf, L. A. (2019). Prevention and control of seasonal influenza with vaccines: recommendations of the Advisory Committee on Immunization Practices—United States, 2019–20 influenza season. MMWR. Recommendations and Reports, 68. https://www.cdc.gov/mmwr/volumes/73/rr/rr7305a1.htmGross, P. A., Hermogenes, A. W., Sacks, H. S., Lau, J., & Levandowski, R. A. (1995). The efficacy of influenza vaccine in elderly persons: a meta-analysis and review of the literature. Annals of Internal medicine, 123(7), 518-527. https://www.ncbi.nlm.nih.gov/books/NBK66348/Puig-Barbera, J., Diez-Domingo, J., Arnedo-Pena, A., Ruiz-Garcia, M., Perez-Vilar, S., Mico-Esparza, J. L., ... & Schwarz-Chavarri, H. (2012). Effectiveness of the 2010–2011 seasonal influenza vaccine in preventing confirmed influenza hospitalizations in adults: A case–case comparison, case-control study. Vaccine, 30(39), 5714-5720. https://www.sciencedirect.com/science/article/pii/S0264410X12010079Kwong, J. C., Campitelli, M. A., Gubbay, J. B., Peci, A., Winter, A. L., Olsha, R., ... & Crowcroft, N. S. (2013). Vaccine effectiveness against laboratory-confirmed influenza hospitalizations among elderly adults during the 2010–2011 season. Clinical infectious diseases, 57(6), 820-827. https://academic.oup.com/cid/article/57/6/820/330306Wilson, K. L., Xiang, S. D., & Plebanski, M. (2017). Inflammatory/noninflammatory adjuvants and nanotechnology—The secret to vaccine design. In Micro and nanotechnology in vaccine development (pp. 99-125). William Andrew Publishing. https://www.sciencedirect.com/science/article/pii/B9780323399814000063Schijns, V. E. (2000). Immunological concepts of vaccine adjuvant activity: Commentary. Current opinion in immunology, 12(4), 456-463. https://doi.org/10.1016/S0952-7915(00)00120-5Share with a friend. Rate, Review, and Subscribe to MedEvidence! Articles to be notified when new episodes are released.Follow us on Social Media:FacebookInstagramTwitterLinkedInTiktokYoutubeFor more great content, including discussions by physicians and clinical research experts, check out the MedEvidence! Podcast and MedEvidence.comThank you for listening!