Inactivity- the imperceived muscle stressor with Dr Paul Greenhaff

Dr Glenn McConell chats with Professor Paul Greenhaff from the University of Nottingham in England. He has been a leader in exercise metabolism research for over 30 years. He was the top global researcher in creatine and exercise for many years. His focus over several years has been on inactivity. We discuss the metabolic effects of inactivity and immobilization on insulin sensitivity and protein synthesis. 0:00. Introduction and Paul’s academic journey 4:00. What is physical inactivity and how is it measured? 8:53. Inactivity itself has negative effects that are under appreciated 10:56. Rodent models of activity/inactivity 13:25. Bed rest + sitting time and insulin resistance 16:02. Rapid reduction in insulin sensitivity with immobilization 18:08. Inactivity not just the opposite of activity? 21:10. After immobilization the responses to exercise is less 22:22. Effect of prolonged immobilization 25:38. Effects on blood flow distribution? 27:55. Effects of immobilizing one arm on the other arm 29:42. Study with 60 days of bed rest 32.15. Does immobilization cause muscle inflammation? 34:45. Exercise increases glucose uptake into bone 36:10. Episodic immobilization and metabolism and muscle mass 41:20. Return of function after immobilization 42:38. Exercise/anabolic resistance 46:51. Inactivity the largest risk factor for death 49:25. Effect of age on muscle mass etc 52:45. Why does insulin sensitivity decrease then plateau 54:13. What’s more important, diet or exercise? 55:32. Rodents/ cells as models 58:26. Do exercise snacks overcome inactivity? 1:00:10. Brain grey matter and activity/inactivity 1:03:30. Exercise effects multiple organs/integrative physiology 1:06:33. Takeaway messages 1:08:04. Why avoiding insulin resistance is so important 1:10:43. Outro (9 secs) Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all. The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University. He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9). Connect with Inside Exercise and Glenn McConell at: Twitter: @Inside_exercise and @GlennMcConell1 Instagram: insideexercise Facebook: Glenn McConell LinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460 ResearchGate: Glenn McConell Email: [email protected] Subscribe to Inside exercise: Spotify: https://open.spotify.com/show/3pSYnNSXDkNLH8rImzotgP?si=Whw_ThaERF6iIKwxutDoNA Apple Podcasts: https://podcastsconnect.apple.com/my-podcasts/show/inside-exercise/03a07373-888a-472b-bf7e-a0ff155209b2 YouTube: https://www.youtube.com/channel/UChQpsAQVEsizOxnWWGPKeag Google podcast, Podcast addict, etc