Inside the Black Box: The Urgency of AI Interpretability episode artwork

EPISODE · Oct 2, 2025 · 1H 2M

Inside the Black Box: The Urgency of AI Interpretability

from Generative Now | AI Builders on Creating the Future · host Lightspeed Venture Partners

Recorded live at Lightspeed’s offices in San Francisco, this special episode of Generative Now dives into the urgency and promise of AI interpretability. Lightspeed partner Nnamdi Iregbulem spoke with Anthropic researcher Jack Lindsey and Goodfire co-founder and Chief Scientist Tom McGrath, who previously co-founded Google DeepMind’s interpretability team. They discuss opening the black box of modern AI models in order to understand their reliability and spot real-world safety concerns, in order to build AI systems of the future that we can trust. Episode Chapters: 00:42 Welcome and Introduction00:36 Overview of Lightspeed and AI Investments03:19 Event Agenda and Guest Introductions05:35 Discussion on Interpretability in AI18:44 Technical Challenges in AI Interpretability29:42 Advancements in Model Interpretability30:05 Smarter Models and Interpretability31:26 Models Doing the Work for Us32:43 Real-World Applications of Interpretability34:32 Philanthropics' Approach to Interpretability39:15 Breakthrough Moments in AI Interpretability44:41 Challenges and Future Directions48:18 Neuroscience and Model Training Insights54:42 Emergent Misalignment and Model Behavior01:01:30 Concluding Thoughts and NetworkingStay in touch:www.lsvp.comX: https://twitter.com/lightspeedvpLinkedIn: https://www.linkedin.com/company/lightspeed-venture-partners/Instagram: https://www.instagram.com/lightspeedventurepartners/Subscribe on your favorite podcast app: generativenow.coEmail: [email protected] content here does not constitute tax, legal, business or investment advice or an offer to provide such advice, should not be construed as advocating the purchase or sale of any security or investment or a recommendation of any company, and is not an offer, or solicitation of an offer, for the purchase or sale of any security or investment product. For more details please see lsvp.com/legal.

Recorded live at Lightspeed’s offices in San Francisco, this special episode of Generative Now dives into the urgency and promise of AI interpretability. Lightspeed partner Nnamdi Iregbulem spoke with Anthropic researcher Jack Lindsey and Goodfire co-founder and Chief Scientist Tom McGrath, who previously co-founded Google DeepMind’s interpretability team. They discuss opening the black box of modern AI models in order to understand their reliability and spot real-world safety concerns, in order to build AI systems of the future that we can trust. Episode Chapters: 00:42 Welcome and Introduction00:36 Overview of Lightspeed and AI Investments03:19 Event Agenda and Guest Introductions05:35 Discussion on Interpretability in AI18:44 Technical Challenges in AI Interpretability29:42 Advancements in Model Interpretability30:05 Smarter Models and Interpretability31:26 Models Doing the Work for Us32:43 Real-World Applications of Interpretability34:32 Philanthropics' Approach to Interpretability39:15 Breakthrough Moments in AI Interpretability44:41 Challenges and Future Directions48:18 Neuroscience and Model Training Insights54:42 Emergent Misalignment and Model Behavior01:01:30 Concluding Thoughts and NetworkingStay in touch:www.lsvp.comX: https://twitter.com/lightspeedvpLinkedIn: https://www.linkedin.com/company/lightspeed-venture-partners/Instagram: https://www.instagram.com/lightspeedventurepartners/Subscribe on your favorite podcast app: generativenow.coEmail: [email protected] content here does not constitute tax, legal, business or investment advice or an offer to provide such advice, should not be construed as advocating the purchase or sale of any security or investment or a recommendation of any company, and is not an offer, or solicitation of an offer, for the purchase or sale of any security or investment product. For more details please see lsvp.com/legal.

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Inside the Black Box: The Urgency of AI Interpretability

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This episode was published on October 2, 2025.

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Recorded live at Lightspeed’s offices in San Francisco, this special episode of Generative Now dives into the urgency and promise of AI interpretability. Lightspeed partner Nnamdi Iregbulem spoke with Anthropic researcher Jack Lindsey and Goodfire...

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