Insulin Resistance Fuels Artery-Clogging Plaque, Early Atherosclerosis

A new study finds insulin resistance and reduced glucose uptake in the heart is linked with early-onset atherosclerosis and heart issues. Sponsored: Support your Workout Sessions and Healthy Hydration with the Electrolyte + Creatine Combo by MYOXCIENCE: https://bit.ly/electrolyte-stix *Save 12% with code podcast at checkout Link to Video and Research: https://bit.ly/3UXLhal Research Mentioned: Devesa, A. et al. Cardiac Insulin Resistance in Subjects With Metabolic Syndrome Traits and Early Subclinical Atherosclerosis. Diabetes Care 46, 2050–2057 (2023). Time Stamps: 00:00 FDG = Fluorodeoxyglucose 00:30 Reduced glucose uptake in the heart is tethered to atherosclerosis. 01:20 LDL levels are not strongly associated with poor outcomes. 02:00 Your heart becomes insulin resistant. 03:05 Those with no glucose uptake in the heart had higher fasting glucose. 03:45 Those with more cardiovascular risk factors had lower LDL. 04:35 The heart can generate energy from fatty acids, carbs, and ketones. 05:00 Cardiac abnormalities are associated with metabolic syndrome. 07:00 Insulin resistance changes muscle and heart muscle. 09:16 Insulin resistance is associated with a progressive decrease of myocardial FDG uptake. 09:50 Cardiovascular risk increases with the decline of FDG uptake. 11:30 Your heart loses the ability to pump blood effectively as it loses ability to utilize different energy substrates. 12:40 Support your heart by supporting your metabolism.