International Journal of Nursing Studies Volume 175, March 2026, 105310

This research study evaluates various medical tools designed to forecast blood clot risks in oncology patients, specifically comparing the traditional Khorana score against several newer, modified versions. By synthesizing data from twenty-eight different studies, the authors sought to determine if these modern adaptations offer superior predictive accuracy for clinical use. The analysis reveals that neither the original model nor its modifications provide a consistently reliable way to distinguish between high and low-risk patients, largely due to a high risk of bias in existing data. Ultimately, the authors conclude that current scoring methods fall short of clinical standards, emphasizing an urgent need for more rigorous, large-scale research to improve patient safety.