Is the Deadliest Condition Preventable? Understanding ASCVD and LDL-C

This episode explores atherosclerotic cardiovascular disease (ASCVD), the leading cause of heart attacks and strokes worldwide. Learn about the role of LDL cholesterol in the development of fatty plaques that harden and block blood vessels, as well as the risks associated with ASCVD, including heart disease and peripheral artery disease. The episode highlights preventive strategies such as healthy lifestyle changes and treatments like statins, PCSK9 inhibitors, and emerging clinical trial therapies. Discover how understanding and managing LDL cholesterol levels can help reduce the burden of this preventable yet most deadly condition.Share with a friend. Rate, Review, and Subscribe to MedEvidence Articles to be notified when new episodes are released.Follow us on Social Media:FacebookInstagramTwitterLinkedInTiktokYoutubeFor more great content, including discussions by physicians and clinical research experts, check out the MedEvidence! podcast. www.MedEvidence.comThank you for listening!References:Makover, M. E., Shapiro, M. D., & Toth, P. P. (2022). There is urgent need to treat atherosclerotic cardiovascular disease risk earlier, more intensively, and with greater precision: A review of current practice and recommendations for improved effectiveness. American Journal of Preventive Cardiology, 12, 100371. https://pmc.ncbi.nlm.nih.gov/articles/PMC9482082/World Health Organization. (7 August, 2024). The top 10 causes of death. [website]. Accessed 16 December, 2024. https://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-deathFerence, B. A., et al. (2017). Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel. European heart journal, 38(32), 2459-2472. https://academic.oup.com/eurheartj/article/38/32/2459/3745109Ferhatbegović, L., Mršić, D., Kušljugić, S., & Pojskić, B. (2022). LDL-C: the only causal risk factor for ASCVD. Why is it still overlooked and underestimated?. Current Atherosclerosis Reports, 24(8), 635-642. https://link.springer.com/article/10.1007/s11883-022-01037-3Mundi, S., et al. (2018). Endothelial permeability, LDL deposition, and cardiovascular risk factors—A review. Cardiovascular research, 114(1), 35-52. https://pmc.ncbi.nlm.nih.gov/articles/PMC7729208/Jebari-Benslaiman, S., et al. (2022). Pathophysiology of atherosclerosis. International journal of molecular sciences, 23(6), 3346. https://www.mdpi.com/1422-0067/23/6/3346Arnett, D. K., et al. (2019). 2019 ACC/AHA guideline on the primary prevention of cardiovascular disease: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Journal of the American College of cardiology, 74(10), e177-e232. https://www.ahajournals.org/doi/10.1161/CIR.0000000000000678Share with a friend. Rate, Review, and Subscribe to MedEvidence! Articles to be notified when new episodes are released.Follow us on Social Media:FacebookInstagramTwitterLinkedInTiktokYoutubeFor more great content, including discussions by physicians and clinical research experts, check out the MedEvidence! Podcast and MedEvidence.comThank you for listening!