ISTAART Research Retrospectives - Professor Alison Goate

In a conversation with Dr. Claire Sexton, Professor Alison Goate discusses her career in dementia research, focusing on two of her landmark papers. The first, published in 1991, identified a missense mutation in the amyloid precursor protein gene associated with familial Alzheimer's disease. The second, published in 2021, integrated Alzheimer's disease genetics and myeloid genomics to identify disease risk regulatory elements and genes. Goate reflects on the evolution of genetic research methods, the shift in focus from amyloid and tau to the immune system, and the importance of global collaboration in Alzheimer's research. She also discusses her personal journey, including her move from the UK to the US, and the impact it had on her research and family life. Professor Goate will be attending the the Alzheimer's Association Tau 2024 Conference - find more information at https://www.alz.org/tau Find a transcript for this podcast, links to bios and the papers discussed in this podcast on our website: https://www.dementiaresearcher.nihr.ac.uk/istaart-research-retrospectives-professor-alison-goate/ -- Like what you hear? Please review, like, and share our podcast - and don't forget to subscribe to ensure you never miss an episode. If you would like to share your own experiences or discuss your research in a blog or on a podcast, drop us a line to [email protected]