Jaggsiekte (OPA)

In this episode of Current Vet, Dr Lottie talks about Jaagsiekte, also known as Ovine Pulmonary Adenocarcinoma (OPA)Find us on TikTok & Instagram: @veterinaryvista Timeline:00:00 Intro00:56 Case03:48 Aetiology & Pathogenesis06:25 Clinical Signs08:28 Diagnosis12:34 Treatment16:53 Current Research18:09 Key Points19:44 OutroRecommended ReadingWorld Organisation for Animal Health (WOAH). (2023). Ovine Pulmonary Adenocarcinoma (Jaagsiekte). In Manual of Diagnostic Tests and Vaccines for Terrestrial Animals. WOAH PDFCousens, C., et al. (2024). Tracking Ovine Pulmonary Adenocarcinoma Development Using an Experimental Jaagsiekte Sheep Retrovirus Infection Model. Genes, 15(8), 1019. https://doi.org/10.3390/genes15081019O’Conor, K. & Chase, C. C. L., (2020). 5-Minute Veterinary Consult: Ruminant, 2nd edn. Wiley-Blackwell. pp. 582-583. Constable, P. D., Hinchcliff, K. W., Done, S. H. & Grünberg, W., (2021). Veterinary Medicine: A Textbook of the Diseases of Cattle, Horses, Sheep, Pigs and Goats, 11th edn. Elsevier, pp. 977–979. ReferencesToma, C. et al. (2025). Overexpression of IL-6 and STAT3 may provide new insights into ovine pulmonary adenocarcinoma development. BMC Veterinary Research, 21, 29.Cousens, C., et al. (2024). Tracking Ovine Pulmonary Adenocarcinoma Development Using an Experimental Jaagsiekte Sheep Retrovirus Infection Model*.* Genes, 15(8), 1019. https://doi.org/10.3390/genes15081019.World Organisation for Animal Health (WOAH). (2023) Ovine Pulmonary Adenocarcinoma (Jaagsiekte). In: Manual of Diagnostic Tests and Vaccines for Terrestrial Animals. WOAH, Paris. Available at: https://www.woah.org/fileadmin/Home/fr/Health_standards/tahm/3.07.08_OPA.pdfO’Conor, K. & Chase, C. C. L., (2020). 5-Minute Veterinary Consult: Ruminant, 2nd edn. Wiley-Blackwell. pp. 582-583.Constable, P. D., Hinchcliff, K. W., Done, S. H. & Grünberg, W., (2021). Veterinary Medicine: A Textbook of the Diseases of Cattle, Horses, Sheep, Pigs and Goats, 11th edn. Elsevier, pp. 977–979.Current Vet is an educational podcast intended for veterinary students, veterinary professionals, and individuals with an interest in veterinary medicine.All content provided in this podcast and its associated materials is for educational and informational purposes only. It is not intended as, and must not be considered a substitute for, professional veterinary advice, diagnosis, or treatment.Any clinical cases discussed in this podcast are fictional, and are designed to reflect typical or likely clinical scenarios for educational purposes. They do not represent specific real-life cases, clients, or animals.While every effort is made to ensure accuracy and alignment with current evidence at the time of publication, veterinary medicine is a rapidly evolving field, and recommendations may change over time.