Jaguars vs 49ers Set for Sept 28 2025 | NFL News

The Jaguars head to Santa Clara on September 28, 2025, for a high-stakes showdown against the 49ers — a prime opportunity for both teams to make early season statements. With McCaffrey leading the charge for SF and health playing a major role, this matchup promises drama, surprises, and plenty of NFL intrigue as training camp and roster moves unfold. Don’t miss it. Listen in comfort:Get a discount on a Soli Pillow: http://solipillow.com/discount/dnn. Advertise on DNN:[email protected] This is an automated, high-level news summary based on public reporting.Report issues to [email protected]. View sources & latest updates:https://sources.thednn.ai/ee7ecfea04a9dce4