Jeff Sperry - Safer, earlier. episode artwork

EPISODE · Jun 18, 2020 · 30 MIN

Jeff Sperry - Safer, earlier.

from Modern Chemistry Podcast · host Paul Orange Ph.D.

One minor clarification  Jeff asked me to make - at around 7:15  he mentions that Vertex  does not do any commercial manufacturing in-house.  Vertex does not perform in-house, commercial scale production of drug substances.You will hear the following terms used during the interview.  I’ve included some descriptions and links to deeper reading. Vertex - Vertex Pharmaceuticals - https://www.vrtx.com/Exotherm – An exothermic reaction is one that gives off heat.  The phrase exotherm is often used as a shortened form of ‘exothermic reaction’.  Unwanted exotherms in process safety cause a potential safety hazard, as they can potentially heat a reaction, beyond the safe limits of available cooling.DSC – Differential Scanning Calorimetry (DSC) is a technique for thermal analysis, in which, the difference in the amount of heat required to increased the temperature of a sample is measured as a function of temperature. It can be used to determine a number of properties of a sample.TSU – The Thermal Screening Unit (TSU) is a system used to screen materials for potential hazards associated with heating.ARC – Accelerating Rate Calorimeter (ARC) is a system used to measure heat generating characteristics of reactions, or reaction components at a range to temperatures.Other reaction data can be determined with this toolGLP Tox Lot. - A Good Laboratory Toxicology lot is a batch of a drug, or drug like material prepared during drug development with the intention of testing safety (and other) properties.API – The Active Pharmaceutical Ingredient (API) is the drug element of a medicine. The drug would be, for example, diluted down with saline solution to make a medicine ready for injection.Buller Empowerment - https://bullerempowerment.com/Taylor Howard – As Jeff mentioned, he follows Taylor on LinkedIn – she’s at https://www.linkedin.com/in/taylorhow If you want to connect with Jeff, or find out more about his lab, you can find:On LinkedIn, Jeff can be found at https://www.linkedin.com/in/jeffreybsperry/On Twitter, Jeff goes by @SafeChem79 - https://twitter.com/SafeChem79 Our theme music is "Wholesome" by Kevin MacLeod (https://incompetech.com)Music from https://filmmusic.ioLicense: CC BY (http://creativecommons.org/licenses/by/4.0/) Connect with me (Paul) at https://www.linkedin.com/in/paulorange/H.E.L. group can be found at www.helgroup.com online,on LinkedIn at https://www.linkedin.com/company/hel-group/on twitter we’re @hel_group, https://twitter.com/hel_groupor search for us on Facebook

Episode metadata supplied by the publisher feed · Published Jun 18, 2020

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Episode 7 of the modern Chemistry podcast is the first one recorded since the start of the global COVID 19 pandemic. Jeff Sperry and I talk about how safety analysis is vital earlier in process development, specifically drug discovery, rather than waiting until you have a new process and being told it's not safe. We also discuss the impact of the pandemic on his work & working practices at the beginning. So, if you’ve had enough virus chat, scroll through the first five minutes after the intro

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