Jennifer Bruin & Lahari Basu on cisplatin exposure and the dysregulation of insulin, Amit Majithia on AF-1 domain inhibition as an insulin sensitization target, and a Sweet Talk special remembrance with Maren Laughlin, Julio Ayala, and Shawn Burgess

Welcome to the April 2025 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the April 2025 issue of Diabetes.  6:30 In the first interview segment, our hosts discuss an article titled "Cisplatin Exposure Dysregulates Insulin Secretion in Male and Female Mice." They're joined by corresponding author Jennifer E. Bruin, BSc, PhD, an associate professor in the Department of Biology and Institute of Biochemistry at Carleton University in Ottawa, Canada, and lead author Lahari Basu, PhD candidate at Carleton University. This article is available for free at doi.org/10.2337/db24-0419.  25:20 Our hosts discuss the latest Paper of the Month, entitled "An Alternatively Translated Isoform of PPARG Suggests AF-1 Domain Inhibition as an Insulin Sensitization Target." They're joined by corresponding author Amit R. Majithia, MD, Associate Professor in the Division of Endocrinology in the Department of Medicine at the UC San Diego School of Medicine. This article is available for free at doi.org/10.2337/db24-0497.  38:55 In the special edition of "Sweet Talk," our hosts reflect on the life and legacy of David Wasserman, PhD, a pioneer in metabolic research with a lasting impact in exercise physiology, glucose metabolism, and diabetes. They're joined by the people who knew him best: Maren Laughlin, PhD, Senior Advisor for Integrative Physiology at the National Institutes of Health, Julio Ayala, PhD, Director of the Vanderbilt Mouse Metabolic Phenotyping Center, and Shawn Burgess, PhD,  professor at UT Southwestern Medical Center in Dallas, Texas.  To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!