EPISODE · Oct 26, 2024 · 0 MIN
今日神经病学最高分文献 - 2024-10-26
from 萌喵读文献-神经病学 · host Meng Zhao
欢迎收听本周的医学前沿播客！一项最新研究发现，随着年龄增长和阿尔茨海默病（AD）的发展，大脑神经元中的cathepsin S（CTSS）水平显著升高，与认知能力下降呈负相关。研究显示，CTSS的过度表达能加剧大脑炎症环境，激活小胶质细胞的M1型炎症表型，并通过CX3CL1-CX3CR1轴和JAK2-STAT3信号通路发挥作用。首次揭示了神经元CTSS在神经元-小胶质细胞“对话”中的作用。此外，使用CTSS选择性抑制剂能改善AD小鼠模型的病理特征。这项研究为阿尔茨海默病的治疗提供了新的潜在靶点，为深入了解衰老和认知衰退的分子机制开辟了新途径。要想深入了解这项研究，别忘了阅读发表于《Aging Cell》杂志的完整论文。下次播客，我们再见！
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