今日肿瘤学最高分文献 - 2025-08-26

Hey there, fellow science enthusiasts! This is your daily dose of cutting-edge research, brought to you by LabCat. Download our app at labcat.com.cn and let AI read the literature for you, boosting your research efficiency like never before. In today's top article, researchers unveil a groundbreaking cellular atlas of the mouse prostate, shedding light on its unique organization and determinants of castration resistance in prostate cancer. By integrating single-cell RNA sequencing and spatial transcriptomics, they discovered lobe-specific luminal epithelial cell types with distinct gene regulatory modules and androgen-responsive programs. Notably, castration-resistant cells activate stress and stemness programs, which are enriched in ADT-resistant tumors. This comprehensive study not only illuminates the importance of lobe-specific contexts for prostate cancer modeling but also reveals potential therapeutic targets to counter castration resistance. A must-read for anyone interested in prostate cancer biology and treatment strategies. Stay tuned for more fascinating research insights!