JPGN Journal Club August 2024: Pediatric Autoimmune Gastritis and Predicting Liver Fibrosis in MASLD

It’s JPGN Journal Club, led by Dr Jake Mann, in your electronic- device speakers, with the July podcast offering. Don’t forget to check out what ESPGHAN has available from July onward, here at https://www.espghan.org/knowledge-center -- in particular on IX.12, AHP Summer School, IX.21, the Young Investigator Forum, and on IX.25, the 5th Liver Transplant School. Jake Mann has chosen for today’s discussion from J Pediatr Gastroenterol Nutr, by Granot et al., a case review of instances of autoimmune gastritis and from Hepatology, by Lefere et al., description and derivation of a proposed “scoring system” to predict fibrosis in non-referral-centre populations of fat children with abnormal serum transaminase activities, sonographic evidence of liver steatosis, and abnormal findings on elastography. The first raises the alarm for pernicious anaemia and gastric-mucosal malignant change in children with iron deficiency. The second hopes to streamline referral patterns for obese pediatric patients seen in the community. So, to quote Sondheim, slightly skewed : “What happens next ? That’s what’s in play / And you wouldn’t want us to give it away.” Have a listen ! Literature Granot M et al. Clinical characteristics and outcomes of pediatric patients with autoimmune gastritis. J Pediatr Gastroenterol Nutr 2024 Jul 16. Online ahead of print. Doi : 10.1002/jpn3.12318. PMID: 39010761. Lefere S et al. Development and validation of pFIB scores for exclusion of significant liver fibrosis in pediatric MASLD. Hepatology 2024 Jul 19. Online ahead of print. Doi : 10.1097/HEP.0000000000001016. PMID : 39028885.