JPGN Journal Club July 2023: Pediatric IBD Cancer Risk, Elevated ALT in Adolescents, and GLIS3-Related Liver Disease

Dr Alex Knisely today is speaking with Dr Andreas Jenke – it’s Journal Club again. Skipping over the June, 2023, number of JPGN, Dr Jenke has chosen from the July number not two but three articles for discussion – from a Scandinavian consortium, Risk Factors of Cancer in Pediatric-Onset Inflammatory Bowel Disease in Denmark and Finland ; from a group in California, Prevalence of Elevated ALT in Adolescents in the US 2011-2018; and from a group in Birmingham, England, Liver Disease inGLIS3 Mutations: Transplant Considerations and Bile Duct Paucity on Explant Histology. Interviewer and interviewee alike consider the Danish / Finnish study a lovely piece of work, the Californian study rather risky in respect of over-medicalisation of a questionably abnormal biomarker value, and the English study as  . . well, as questionable. What will your opinions be?