JPGN Journal Club May 2026: Emerging Insights into Eosinophilic Oesophagitis

Welcome to the third ESPGHAN Journal Club of 2026, with Dr Jake Mann! Jake has chosen for today’s session two studies in eosinophilic oesophagitis – for convenience’ sake, henceforward “EOE”. One describes an interesting rise in instances of diagnosed EOE in two regions of Spain; the other provides data suggesting that to assess EOE by both histopathologic and molecular-biologic criteria as bipartite, or with two distinct and perhaps separable components, inflammation and remodelling, may be of prognostic value. What might public-health officials do to address the purported rise in the incidence of Spanish EOE? Will histopathologic studies of EOE acquire new life? The answer to both is: “Anything can, and probably will, happen in Spring.” For details, listen – or read – further: The bibliographic citations are below. LiteratureArias A et al. Prevalence of eosinophilic esophagitis doubles in less than a decade: A population-based study in 2 regions of Spain. J Investig Allergol Clin Immunol 2026 Mar 30:0. Doi: 10.18176/jiaci.1161. Online ahead of print. PMID: 41910381.Eindor‐Abarbanel A et al. Beyond eosinophils: A proteomic dissection of remodeling and inflammation in suspected eosinophilic esophagitis. J Pediatr Gastroenterol Nutr 2026 Apr; 82(4):1078‐1087. Doi: 10.1002/jpn3.70347. PMID: 41536225. PMCID: PMC13050820.