Jun 30, 2026 | NEJM Retracts Tavneos Pivotal Trial; Ionis Tryngolza PDUFA Today

NEJM retracts Amgen's ADVOCATE study after FDA findsendpoint data for 9 patients re-evaluated post-unblinding. Plus: Ionis faces the Tryngolza sNDA PDUFA in severe hypertriglyceridemia, AbbVie's Epkinly delivers chemo-free PFS in R/R DLBCL, Ipsen acquires Kartos for up to $1.75B,and Roche enters the TED race with Enspryng Priority Review.Visit us at www.thepharmacloseout.compharma, pharmaceutical, FDA, clinical trials, biotech, drugapprovals, healthcare, pharma podcast, The Pharma Closeout, Tavneos, avacopan,Amgen, NEJM retraction, ADVOCATE study, olezarsen, Tryngolza, IonisPharmaceuticals, epcoritamab, Epkinly, AbbVie, Genmab, DLBCL, Enspryng,satralizumab, Roche, thyroid eye disease, Ipsen, Kartos Therapeutics,navtemadlin, myelofibrosis, Zymeworks, Theravance, ZORYVE, roflumilast,Arcutis, Foundayo, orforglipron, Eli Lilly, Gilead, efzimfotase alfa,AstraZeneca, hypophosphatasia, FDA PreCheck, Lilly, Regeneron