Ketamine & Cocaine: Ranking Drugs for Longevity (Part 1) episode artwork

EPISODE · Sep 4, 2025 · 50 MIN

Ketamine & Cocaine: Ranking Drugs for Longevity (Part 1)

from Bryan Johnson Podcast · host Bryan Johnson

Can doing lines help you live longer? That depends on what you’re taking. In this three-part series, I’m ranking drugs based on their ties to longevity, starting with ketamine and cocaine. I tested ketamine on myself to study its impacts on the brain — here’s what we found.   Study Links: Ketamine’s Effects on Epigenetic Age  Extending Ketamine’s Therapeutic Window Ibogaine Therapy for PTSD  Hosts: Bryan Johnson: Blueprint Founder Kate Tolo: Blueprint Co-Founder Dr. Mike Mallin: Lead Physician for Bryan Johnson Connect:  X: https://x.com/bryan_johnson YouTube: https://www.youtube.com/@BryanJohnson Instagram:  https://www.instagram.com/bryanjohnson   TikTok:  https://www.tiktok.com/@_bryan_johnson_ Chapters:  00:00 - Introduction  03:14 - Social Norms Around Drugs  08:59 - Psychedelics as Therapy: Overview  10:20 - Cocaine  17:15 - Fentanyl Dangers  23:27 - Ketamine: Brain Impacts + Longevity  41:29 - Measuring The Impacts of Psychedelics   47:51 - Longevity Rankings: Cocaine + Ketamine

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Ketamine & Cocaine: Ranking Drugs for Longevity (Part 1)

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