"Ketamine, Yale Psychiatry & the Future of Mental Health" with Dr. John Krystal

In this landmark episode of The Gold Standard, Dr. Mark Gold speaks with Dr. John Krystal, Chair of Psychiatry at Yale School of Medicine and the longtime Editor‑in‑Chief of Biological Psychiatry. This in‑depth conversation traces the scientific origins of ketamine’s rapid antidepressant effects, the unique neuroscience culture at Yale, and how mechanism‑driven psychiatry is reshaping treatment for depression, PTSD, addiction, and beyond.This episode goes far beyond ketamine alone. Dr. Krystal reflects on how psychiatry moved from monoamine theories toward circuit‑based neuroscience, and why depression, trauma, and addiction require fundamentally different ways of thinking.