Knives Out

The rewrite today is for Knives Out. The deep dive is about pain management of musculoskeletal injuries. Movie suggestion form: https://tinyurl.com/8pa8svey References used in this episode Clinical Practice Guidelines for Pain Management in Acute Musculoskeletal Injury by the Orthopaedic Trauma Association Musculoskeletal Pain Task Force https://pubmed.ncbi.nlm.nih.gov/30681429/ Nonpharmacologic and Pharmacologic Management of Acute Pain From Non-Low Back, Musculoskeletal Injuries in Adults: A Clinical Guideline From the American College of Physicians and American Academy of Family Physicians INFOGRAPHIC INCLUDED https://pubmed.ncbi.nlm.nih.gov/32805126/ Oxycodone vs ibuprofen vs. combo tx for the treatment of pain after abdominal or pelvic surgery in women RCT https://pubmed.ncbi.nlm.nih.gov/15763605/ RCT topical diclofenac/menthol vs. placebo for ankle sprain pain https://pubmed.ncbi.nlm.nih.gov/28345425/ RCT topical diclofenac gel, ibuprofen gel, and ibuprofen gel with levomenthol for musculoskeletal injuries https://pubmed.ncbi.nlm.nih.gov/31353997/ RCT: ketorolac 60 mg IM vs ibuprofen 800 mg PO for acute musculoskeletal pain https://pubmed.ncbi.nlm.nih.gov/7618770/ RCT: ketorolac 60 mg vs 15 mg for acute musculoskeletal pain https://pubmed.ncbi.nlm.nih.gov/34365063/ Post-market surveillance study of ketorolac and GI bleeds https://pubmed.ncbi.nlm.nih.gov/8569017/ Nested-case control for NSAID-associated heart failure admissions https://pubmed.ncbi.nlm.nih.gov/27682515/ Drug Information summary about ketorolac duration by Christie Denton, PharmD, BCPS https://dig.pharmacy.uic.edu/faqs/2022-2/september-2022-faqs/what-evidence-is-there-for-the-5-day-maximum-with-the-use-of-ketorolac/