KOL Conversation on Amyloidosis

In this expert-led discussion from GI ReConnect, Dr. David Kunkel is joined by Dr. Lucinda Harris and Dr. Ali Rezaie to explore the evolving understanding of gastrointestinal involvement in amyloidosis. The panel unpacks how misfolded protein deposition can lead to a wide spectrum of GI symptoms—from diarrhea, weight loss, and gastroparesis to small intestinal bacterial overgrowth (SIBO), bleeding, and malnutrition. They walk through diagnostic strategies, including the importance of requesting Congo red staining during biopsy and maintaining a high index of suspicion in patients with unexplained GI symptoms, particularly those with systemic red flags. Real-world insights into multidisciplinary management—including collaboration with cardiology, hematology, nephrology, and neurology—highlight the systemic nature of amyloidosis and the need for early intervention. The panel also reviews emerging treatment options for AL, AA, and ATTR amyloidosis, emphasizing how timely diagnosis can prevent irreversible organ damage and dramatically improve outcomes. With personal reflections, practical pearls, and guidance for both clinicians and patients, this episode is a must-watch for gastroenterologists navigating complex, multisystem diseases.