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Lactated Ringer’s vs. 0.9% Saline in Sepsis: Does Fluid Choice Affect Survival?

EPISODE · Feb 26, 2025 · 11 MIN

Lactated Ringer’s vs. 0.9% Saline in Sepsis: Does Fluid Choice Affect Survival?

from Saving Lives Podcast: Critical Care w/eddyjoemd · host Eddy Joe Gutierrez, MD

In this episode of the Saving Lives Podcast, we review a 2025 study from Critical Care Medicine comparing lactated Ringer’s and normal saline for initial fluid resuscitation in sepsis-induced hypotension. The findings suggest that LR may improve survival and increase hospital-free days compared to NS, supporting current guidelines favoring balanced crystalloids. Tune in for a deep dive into the study’s results and clinical implications!The Vasopressor & Inotrope HandbookI have written "The Vasopressor & Inotrope Handbook: A Practical Guide for Healthcare Professionals," a must-read for anyone caring for critically ill patients (check out the reviews)! You have several options to get a physical copy. Amazon: ⁠⁠⁠⁠⁠https://amzn.to/47qJZe1⁠⁠⁠⁠⁠ (Affiliate Link)My Store: ⁠⁠⁠⁠⁠https://eddyjoemd.myshopify.com/products/the-vasopressor-inotrope-handbook⁠⁠⁠⁠⁠ (Use "podcast" to save 10%)Citation: Gelbenegger G, Shapiro NI, Zeitlinger M, Jilma B, Douglas IS, Jorda A. Lactated Ringer's or Normal Saline for Initial Fluid Resuscitation in Sepsis-Induced Hypotension. Crit Care Med. 2025 Feb 19. doi: 10.1097/CCM.0000000000006601. Epub ahead of print. PMID: 39969246.

What this episode covers

In this episode of the Saving Lives Podcast, we review a 2025 study from Critical Care Medicine comparing lactated Ringer’s and normal saline for initial fluid resuscitation in sepsis-induced hypotension. The findings suggest that LR may improve survival and increase hospital-free days compared to NS, supporting current guidelines favoring balanced crystalloids. Tune in for a deep dive into the study’s results and clinical implications!The Vasopressor & Inotrope HandbookI have written "The Vasopressor & Inotrope Handbook: A Practical Guide for Healthcare Professionals," a must-read for anyone caring for critically ill patients (check out the reviews)! You have several options to get a physical copy. Amazon: ⁠⁠⁠⁠⁠https://amzn.to/47qJZe1⁠⁠⁠⁠⁠ (Affiliate Link)My Store: ⁠⁠⁠⁠⁠https://eddyjoemd.myshopify.com/products/the-vasopressor-inotrope-handbook⁠⁠⁠⁠⁠ (Use "podcast" to save 10%)Citation: Gelbenegger G, Shapiro NI, Zeitlinger M, Jilma B, Douglas IS, Jorda A. Lactated Ringer's or Normal Saline for Initial Fluid Resuscitation in Sepsis-Induced Hypotension. Crit Care Med. 2025 Feb 19. doi: 10.1097/CCM.0000000000006601. Epub ahead of print. PMID: 39969246.

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Lactated Ringer’s vs. 0.9% Saline in Sepsis: Does Fluid Choice Affect Survival?

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How long is this episode of Saving Lives Podcast: Critical Care w/eddyjoemd?

This episode is 11 minutes long.

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This episode was published on February 26, 2025.

What is this episode about?

In this episode of the Saving Lives Podcast, we review a 2025 study from Critical Care Medicine comparing lactated Ringer’s and normal saline for initial fluid resuscitation in sepsis-induced hypotension. The findings suggest that LR may improve...

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