Larazotide: The Gatekeeper Peptide

If you are a woman in your 40s or 50s who has developed bloating, food sensitivities, brain fog, or joint pain that nobody can explain — and your labs keep coming back “normal” — this episode is for you. Dr. Tracy Page walks through the science of why estrogen decline damages the gut barrier, the bidirectional feedback loop driving your symptoms, and the peptide called larazotide that targets the exact mechanism behind your inflammation. Featuring the case of “Diane,” a 51-year-old patient with a three-year symptom list and six prior doctors who never gave her an answer.In this episode, you will learn: why estrogen is a gut hormone, not just a reproductive one; the bidirectional damage loop between hormones and the gut microbiome; what zonulin is and why it controls every leaky gut symptom; how larazotide works mechanistically and why it is unlike any other gut intervention; the exact 12-week protocol used in clinical practice; and five things you can do this week to start sealing your gut barrier even before you see a physician.Key Topics Covered:How estrogen decline increases gut permeability in perimenopauseWhy bloating, brain fog, and joint pain often begin in midlifeWhat zonulin does and how it drives leaky gutHow larazotide helps seal the gut barrierWhy gut healing should come before hormone therapyIf you’ve been told your symptoms are “just menopause,” this episode offers a powerful new perspective. Listen to discover why your gut may hold the key to feeling like yourself again. *********************Midlife Clarity with Dr. Tracy Page is a podcast for women over 40 navigating hormones, metabolism, strength, and healthy aging during midlife, perimenopause, and menopause.Connect with Dr. Page:Dr. Tracy Instagram: https://www.instagram.com/tracypagemd/Dr. Tracy Facebook: https://www.facebook.com/drtracypage/Connect with The Wisconsin Institute of Functional Medicine (WIFM):Website: Wisconsin Institute of Functional Medicine (WIFM)           https://wisconsinfunctionalmed.com/WIFM Instagram: https://www.instagram.com/wisconsinfunctionalmed/YouTube - Wisconsin Institute of Functional Medicine: https://www.youtube.com/channel/UC_oZu2b83V06C0szpKmUU9gDISCLAIMER: The information shared on this podcast is for educational purposes only and is not intended as medical advice. It does not replace a consultation with your own physician or qualified health care provider. Always seek professional medical guidance regarding your personal health concerns.© 2026 Dr. Tracy Page