“LAUNCHING THE GENESIS MISSION” Executive Order

“LAUNCHING THE GENESIS MISSION” Executive OrderThe U.S. is framed as being in a global race for AI leadership.The administration wants a historic, whole‑of‑nation effort, compared explicitly to the Manhattan Project.The Genesis Mission will:Intended outcomes:Genesis Mission is formally established as a national effort focused on AI‑driven scientific discovery for key national challenges.Secretary of Energy (DOE):Assistant to the President for Science and Technology (APST):The American Science and Security Platform is the core infrastructure for the Mission.It must provide, in an integrated and secure way:High‑performance computingDOE supercomputers + secure cloud AI environments for large‑scale model training, simulation, inference.AI modeling and analysis frameworksAI agents to explore design options, analyze experiments, and automate workflows.Computational toolsAI‑enabled predictive models, simulations, and design‑optimization tools.Domain‑specific foundation modelsAcross scientific domains relevant to the challenges.Secure dataset accessProprietary, feder­ally curated, and open datasets, plus synthetic data.All with proper classification, privacy, IP, and federal data standards.Experimental & production toolsFor AI‑augmented labs and manufacturing, including autonomous experimentation.Security & timelines:Platform must meet national security and cybersecurity standards, including supply‑chain security.Within 90 days:Within 120 days:Within 240 days:Within 270 days:Within 60 days, the Secretary of Energy must submit at least 20 national S&T challenges that AI could address, spanning domains like:Advanced manufacturingBiotechnologyCritical materialsNuclear fission and fusion energyQuantum information scienceSemiconductors and microelectronicsWithin 30 days after that, the APST, via NSTC:Reviews and expands this into the initial official challenge list, including agency‑proposed items.Participating agencies will then:Use the Platform to do R&D aligned with this challenge list, consistent with their missions and appropriations.Annually, DOE updates the challenge list with APST and NSTC:Reflecting progress, new needs, and admin priorities.APST via NSTC, with the Federal CDO Council and Chief AI Officer Council, will:Align agencies’ AI programs, data, and R&D with Mission goals, avoid duplication, and promote interoperability.Identify data sources for the Mission.Develop plans and resources to integrate agency data/infrastructure with risk‑based cybersecurity.Launch funding opportunities/prizes to spur private‑sector AI science aligned with Mission goals.Coordinate funding and experimental resources across agencies.Talent programs:APST will help set up fellowships, internships, and apprenticeships focused on AI applied to the national challenges.Participants can be placed at DOE labs and other federal research facilities and trained on the Platform.External partnerships:The Secretary of Energy, with APST and the Special Advisor for AI and Crypto, will:DOE must:APST via NSTC should also look for international science collaboration opportunities where appropriate.Within 1 year, and then annually, DOE must report to the President (via APST and OMB) on:Platform operational status and capabilities.Progress on integration across DOE labs and federal partners.User engagement, including students and training.Research outcomes: advances, publications, prototype technologies.Public‑private partnerships: scope, results, commercialization.Any needs or recommendations for authorities or interagency support.The order does not:Implementation must comply with law and available appropriations.It creates no enforceable legal rights for private parties.Publication costs are paid by the Department of Energy.Signed by President Donald J. Trump, November 24, 2025.