Leave a Gap for the Light

What this episode covers

This release contains only the music track from Base by Base Episode 187. Song title: Leave a Gap for the LightOriginal Base by Base episode: 187: Gapped scheduling: CRLX101 + olaparib Phase I trial Article metadata:Article title: Tumor-targeted top1 inhibitor delivery with optimized parp inhibition in advanced solid tumors: a phase i trial of gapped schedulingJournal: Nature CommunicationsDOI: 10.1038/s41467-025-64509-5Reference: Nature Communications (2025) 16:9457; https://doi.org/10.1038/s41467-025-64509-5 Lyrics:Verse 1Late-night monitors, steady fluorescent glowA small white pill and a slow-release flowTwo ways to break what a tumor will hideBut we learned not to hit it all at once—We learned to time the tide Pre-ChorusHold back, then press inLet the marrow breathe, let the next round beginDamage shows up like a signal flareIn the roots of hair, in the blood we carry there ChorusLeave a gap for the light, leave a gap for the fightStep, then strike—make the timing rightThread the needle through a dangerous tuneBreak the chain, trap the repair too soonLeave a gap for the light, and we rise through the night Verse 2Nanoparticles drifting, patient and preciseA quiet kind of power at a measured priceNo clash in the bloodstream, no crossing of lanesJust a longer run and controlled release—And a plan that reins in pain BridgeWe don’t call it a cure, but we saw it moveA couple steps forward when there wasn’t much roomSome held their ground, some turned the pageAnd the warning signs stayed mostly manageable—So we keep the courage, keep the gauge Final ChorusLeave a gap for the light, leave a gap for the fightStep, then strike—make the timing rightLet the damage mark bloom, then close the doorPush the dose up near the edge, still asking for moreLeave a gap for the light, and we rise through the night

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