Les mythes en médecine d'urgence - Partie 5

Perrine Truong accueille Nicolas Beysard pour ce 5e épisode des mythes en médecine d'urgence. Les deux mythes discutés ici : l’hydratation intraveineuse permet pas de faire baisser plus rapidement le taux d’alcoolémie des patients ethylisés aigu aux urgences, et le tramadol est un opiacé faible et peu dangereux.Références du podcast :Homma Y, Shiga T, Hoshina Y, et al. IV crystalloid fluid for acute alcoholic intoxication prolongs ED length of stay. Am J Emerg Med. 2018 Apr;36(4):673-676.Terayama T, Sasa R, Nakatani Y, et al. Effect of intravenous fluid therapy for acute alcohol intoxication on length of time from arrival at the emergency department until awakening: A prospective observational cohort study. Acute Med Surg. 2023 May 3;10(1):e841.Perez SR, Keijzers G, Steele M, Byrnes J, Scuffham PA. Intravenous 0.9% sodium chloride therapy does not reduce length of stay of alcohol-intoxicated patients in the emergency department: a randomised controlled trial. Emerg Med Australas. 2013 Dec;25(6):527-34.Li J, Mills T, Erato R. Intravenous saline has no effect on blood ethanol clearance. J Emerg Med. 1999 Jan-Feb;17(1):1-5.Maillard, A., Beysard, N., Mythes en médecine d’urgence : prises en charge intrahospitalières, Rev Med Suisse, 2017/570 (Vol.13), p. 1378–1380.Etat de lieux de la consommation des antalgiques opioïdes et leurs usage. ANSM, février 2019.Jeong S, Tchoe HJ, Li J, Shin JY. All-Cause Mortality Associated with Tramadol Use: A Case-Crossover Study. Drug Saf. 2019 Jun;42(6):785-796.Xie J, Strauss VY, Martinez-Laguna D, et al. Association of Tramadol vs Codeine Prescription Dispensation With Mortality and Other Adverse Clinical Outcomes. JAMA. 2021 Oct 19;326(15):1504-1515.Zeng C, Dubreuil M, LaRochelle MR, Lu N, Wei J, Choi HK, Lei G, Zhang Y. Association of Tramadol With All-Cause Mortality Among Patients With Osteoarthritis. JAMA. 2019 Mar 12;321(10):969-982.Stamer UM, Musshoff F, Kobilay M, Madea B, Hoeft A, Stuber F. Concentrations of tramadol and O-desmethyltramadol enantiomers in different CYP2D6 genotypes. Clin Pharmacol Ther. 2007 Jul;82(1):41-7.Grond S, Sablotzki A. Clinical pharmacology of tramadol. Clin Pharmacokinet. 2004;43(13):879-923.Roussin A, Soeiro T, Fouque C, et al. Increase of high-risk tramadol use and harmful consequences in France from 2013 to 2018: Evidence from the triangulation of addictovigilance data. Br J Clin Pharmacol. 2022 Aug;88(8):3789-3802.Hassamal S, Miotto K, Dale W, Danovitch I. Tramadol: Understanding the Risk of Serotonin Syndrome and Seizures. Am J Med. 2018 Nov;131(11):1382.e1-1382.e6.Thiels CA, Habermann EB, Hooten WM, Jeffery MM. Chronic use of tramadol after acute pain episode: cohort study. BMJ. 2019 May 14;365:l1849.Nau, J., L’arbre à tramadol existe : il prend racine en Afrique, Rev Med Suisse, 2013/401 (Vol.9), p. 1862–1863.