Link Between Obesity and Inflammation with Dr. Isabelle Amigues, MD

Isabelle Amigues, MD, CEO and Founder of UnabridgedMD in Rheumatology  Isabelle Amigues, MD, is a rheumatologist based in Denver, Colorado. She honed her expertise by studying in Paris, as well as at Columbia University, in New York City. At age 40 she was diagnosed with stage IV metastatic breast cancer. A timely meeting with a non-traditionally trained practitioner taught her a different approach to disease where she experienced the power of meditation, visualization, energy healing, and love. Her journey through cancer inspired her to learn more about these alternative techniques and she now blends western medicine and eastern techniques into her practice at UnabridgedMD.Website: UnabridgedMD.comYoutube: @Rheumatology101Instagram: @unabridgedmdFacebook: @UnabridgedMDX: @UnabridgedMDFat tissue isn’t just “extra weight.” It can function like an immune-active organ, packed with inflammatory cells that quietly raise the baseline inflammation in your body. That one shift in understanding changes how we think about obesity, insulin resistance, and chronic disease and it may explain why conditions like rheumatoid arthritis and psoriatic arthritis can be harder to control when excess adipose tissue is in the mix.We’re joined by Dr. Isabelle Amig, a board-certified rheumatologist in Denver and the host of Unabridged MD, to unpack what the research and real-world clinic patterns are showing. We talk about what doctors literally see in fat biopsies, why ongoing inflammation becomes “fuel on the fire” for autoimmune disease, and how obesity can raise risk and severity in inflammatory arthritis. Then we connect the dots to cardiometabolic health, including why systemic inflammation also matters for cardiovascular disease and kidney outcomes.We also go deep on GLP-1 receptor agonists and why their impact may extend beyond appetite and weight loss. Dr. Amig shares why some patients report feeling better fast, sometimes before significant weight changes, and how emerging science suggests a direct anti-inflammatory effect at the cellular level. Finally, we address the stigma head-on: insulin resistance is common, menopause and biology play a role, and using evidence-based obesity medicine isn’t a moral failure.If this conversation helps you, share it with someone who needs clearer health information, then subscribe and leave a review so more people can find the show.👩🏼‍⚕️ Live in Missouri? Want to be my patient?Telehealth clinic: https://missourimetabolichealth.com🥑 Have questions you want answered on the podcast? Email [email protected]✨Freebies✨Anti-Obesity Medication OptionsHow To Prevent DiabetesHealthy Habits WorkbookPreventative Health Checklist🤗 Socials:Instagram: https://www.instagram.com/dr.lindsayogle/TikTok: https://www.tiktok.com/@dr..lindsay.ogle?_t=8prC4VUQZ5i&_r=1YouTube: https://www.youtube.com/channel/UCMV0X6U0JLZgRMiNwGtmpeg