Lipase in the Diagnosis of Acute Pancreatitis: How to Eliminate Unnecessary Testing

Amylase testing has long been used as a diagnostic tool for pancreatitis, despite amylase levels not being a definitive indicator of pancreatitis. Lipase offers a more useful diagnostic result, as its readings are a better indicator of inflammation of the pancreas, according to James Nichols, PhD, a member of the CAP Quality Practices Committee. Ordering a combination of amylase and lipase is a common practice, but the combination does not increase the sensitivity over a single test. Likewise, serial testing of lipase does not offer better monitoring or treatment. As part of the CAP Test Ordering Program, a new module (https://capatholo.gy/3Du78fr) provides information and resources for the pathologist to address unnecessary testing volumes in the laboratory while still providing effective patient care, as Dr. Nichols explains in this CAPcast.