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EPISODE · Mar 6, 2026 · 3 MIN

Lipolysis, Beta-oxidation and Ketogenesis

from Metabolism Made Easy · host A J Ghalayini, Ph.D.

Lipolysis in adipose tissue is initiated by activation of Hormone-Sensitive Lipase by epinephrine during fasting. The fatty acids released in the bloodstream provide an alternative fuel source for other tissues like the liver and muscle. This switch to using fatty acids for energy spares glucose use during fasting. In addition, excess acetyl CoA in the liver is used to produce ketone bodies that can serve as an alternative energy source for many tissues.

What this episode covers

Lipolysis in adipose tissue is initiated by activation of Hormone-Sensitive Lipase by epinephrine during fasting. The fatty acids released in the bloodstream provide an alternative fuel source for other tissues like the liver and muscle. This switch to using fatty acids for energy spares glucose use during fasting. In addition, excess acetyl CoA in the liver is used to produce ketone bodies that can serve as an alternative energy source for many tissues.

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Lipolysis, Beta-oxidation and Ketogenesis

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Frequently Asked Questions

How long is this episode of Metabolism Made Easy?

This episode is 3 minutes long.

When was this Metabolism Made Easy episode published?

This episode was published on March 6, 2026.

What is this episode about?

Lipolysis in adipose tissue is initiated by activation of Hormone-Sensitive Lipase by epinephrine during fasting. The fatty acids released in the bloodstream provide an alternative fuel source for other tissues like the liver and muscle. This switch...

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