Louisville vs Ole Miss Playoff Preview | Louisville Football News

College football’s biggest early-season showdown kicks off in Nashville as No. 24 Louisville clashes with No. 9 Ole Miss in the historic Music City Kickoff — both chasing playoff dreams on the opening weekend of the 2026 season. Led by explosive running back Isaac Brown and a rising offense, Louisville seeks redemption after a 2021 loss to Ole Miss. Meanwhile, Pete Golding’s Rebels roll out star QB Trinidad Chambliss and rushing dynamo Kewan Lacy, aiming to prove their new era is built for domination. Tune in at 7:30 PM ET on ABC for a clash that could set the tone for the entire season. Listen in comfort:Get a discount on a Soli Pillow: http://solipillow.com/discount/dnn. Advertise on DNN:[email protected] This is an automated, high-level news summary based on public reporting.Report issues to [email protected]. View sources & latest updates:https://sources.thednn.ai/9eb5f817221a7927