Louisville vs Ole Miss Top 10 Showdown | Louisville News

Louisville Cardinals hit the ground running in 2026 with a high-stakes showdown against No. 9 Ole Miss Rebels—college football’s only ranked-vs-ranked opener of the week. After a stellar 9-4 season and nine wins in each of Coach Jeff Brohm’s years, Louisville returns key talent like ACC Rookie of the Year Isaac Brown and debuts Ohio State transfer Lincoln Kienholz at QB. Facing a top-10 squad that reached the CFP semifinals last year, this neutral-site clash in Nashville could be the statement game that propels them into playoff contention. Kickoff: 7:30 PM ET, live on ABC. Listen in comfort:Get a discount on a Soli Pillow: http://solipillow.com/discount/dnn. Advertise on DNN:[email protected] This is an automated, high-level news summary based on public reporting.Report issues to [email protected]. View sources & latest updates:https://sources.thednn.ai/eb7440c66b5acaa6