Louisville's Run Game vs SMU | Louisville Football News

This weekend’s showdown between Louisville and SMU could be the biggest game of the season — with ACC Championship implications on the line. Despite a brutal 0-4 all-time record against SMU, the Cardinals have a golden chance to break the streak by dominating the run game. Led by preseason All-American Isaac Brown and a loaded backfield, Louisville targets SMU’s weak run defense — ranked 82nd nationally and surrendering over 127 yards per game. With Brown poised for a breakout performance and Keyjuan Brown stepping up, this could be the game that propels Louisville into Charlotte. Listen in comfort: Get a discount on a Soli Pillow: http://solipillow.com/discount/dnn. Advertise on DNN: [email protected] This is an automated, high-level news summary based on public reporting. Sources: https://bigredlouie.com/louisville-football-has-the-perfect-blueprint-to-upset-no-16-smu-this-weekend- More coverage & latest updates: https://sources.thednn.ai/104c7b443ed3a6b0 Report issues to [email protected].