Lp(a), the Little Hellfire Engine That Could (Kill You)

In this episode, we embark on a journey through the intricate highways of the bloodstream, exploring the fascinating world of lipoproteins. These ingenious packages, comprised of lipids and proteins, navigate the watery terrain of blood, ferrying essential nutrients and molecules like cholesterol to cells throughout the body. But our adventure takes a dark turn as we encounter the menacing Lp(a), a variant of lipoprotein with the potential to wreak havoc on the cardiovascular system. As we navigate the complexities of high Lp(a) levels and their genetic underpinnings, we illuminate the ongoing quest for innovative treatments and the importance of clinical trials in combating this formidable foe. Join us as we embark on this enlightening odyssey through the realm of lipoproteins, shedding light on their mysteries and paving the way for a healthier future.Participate in clinical research!www.ENCOREdocs.comShare with a friend. Rate, Review, and Subscribe to the ENCORE Research Group podcast to be notified when new episodes are released.Follow us on Social Media:FacebookInstagramTwitterLinkedInTiktokFor more great content, including discussions by physicians and clinical research experts, check out the MedEvidence podcast. www.MedEvidence.comThank you for listening!References:Biggerstaff, K. D., & Wooten, J. S. (2004). Understanding lipoproteins as transporters of cholesterol and other lipids. Advances in physiology education, 28(3), 105-106. https://journals.physiology.org/doi/full/10.1152/advan.00048.2003Devaraj, S., Semaan, J. R., & Jialal, I. (2019). Biochemistry, apolipoprotein B. https://europepmc.org/article/NBK/nbk538139Feingold, K. R. (2024). Introduction to lipids and lipoproteins. Endotext [Internet]. https://www.ncbi.nlm.nih.gov/books/NBK305896/Kamstrup, P. R., Neely, R. D. G., Nissen, S., Landmesser, U., Haghikia, A., Costa-Scharplatz, M., ... & Nordestgaard, B. G. (2024). Lipoprotein (a) and cardiovascular disease: sifting the evidence to guide future research. European Journal of Preventive Cardiology, zwae032. https://academic.oup.com/eurjpc/advance-article/doi/10.1093/eurjpc/zwae032/7585314Koschinsky, M. L., Stroes, E. S., & Kronenberg, F. (2023). Daring to dream: Targeting lipoprotein (a) as a causal and risk-enhancing factor. Pharmacological Research, 106843. https://www.sciencedirect.com/science/article/pii/S1043661823001998Lampsas, S., Xenou, M., Oikonomou, E., Pantelidis, P., Lysandrou, A., Sarantos, S., ... & Siasos, G. (2023). Lipoprotein (a) in Atherosclerotic Diseases: From Pathophysiology to Diagnosis and Treatment. Molecules, 28(3), 969. https://www.mdpi.com/1420-3049/28/3/969Schmidt, K., Noureen, A., Kronenberg, F., & Utermann, G. (2016). Structure, function, and genetics of lipoprotein (a). Journal of lipid research, 57(8), 1339-1359. https://www.jlr.org/article/S0022-2275(20)35208-1/fulltextShare with a friend. Rate, Review, and Subscribe to MedEvidence! Articles to be notified when new episodes are released.Follow us on Social Media:FacebookInstagramTwitterLinkedInTiktokYoutubeFor more great content, including discussions by physicians and clinical research experts, check out the MedEvidence! Podcast and MedEvidence.comThank you for listening!