Lynch Syndrome and Genetic Testing

An episode of the The Onco'Zine Brief podcast, hosted by Peter Hofland, titled "Lynch Syndrome and Genetic Testing" was published on May 24, 2022 and runs 48 minutes.

May 24, 2022 ·48m · The Onco'Zine Brief

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Summary

After checking your cholesterol, hemoglobin A1C, and glucose level during your annual wellness check, your primary care phycisian says: 'It looks like we haven't done your genome. Why don't we do that?' How would you respond? If you have a genetic mutation that increases your risk for a treatable medical condition, would you want to know? For many people the answer is yes. But typically, such information has not been a part of routine primary care.In this episode Peter Hofland PhD talks with Noelle Carbognin and Elizabeth Chao, MD, FACMG, a Medical Geneticist at UC Irvine about about Lynch Syndrome, a type of inherited cancer syndrome associated with a genetic predisposition to different cancer types, including Colorectal cancer and about various aspects of genetic testing, new technologies, including next generation sequencing technology, and the potential future possibilities and benefits of genetic testing in preventing disease.[1][2]About The Onco'Zine BriefThe Onco'Zine Brief is distributed in the United States via PRX (Public Radio Exchange). In the United Kingdom and Europe, the program is distributed via UK Health Radio (UKHR). And the program can be downloaded via most podcasts and streaming media services, including iTunes, Spotify, TuneIn, and iHeart Radio.For more information about The Onco'Zine Brief or how to sponsor or support this public radio broadcast and podcast, visit: http://www.oncozine.com to download our Media Kit or visit Patreon at https://www.patreon.com/theoncozinebrief to support the program.For more information about cancer and cancer treatments, visit our online journal Onco'Zine at www.oncozine.comTo sign up for The Onco'Zine Newsletter (open for residents of the United States only), text the word CANCER to 66866.Reference[1] Espenschied CR, LaDuca H, Li S, McFarland R, Gau CL, Hampel H. Multigene Panel Testing Provides a New Perspective on Lynch Syndrome. J Clin Oncol. 2017 Aug 1;35(22):2568-2575. doi: 10.1200/JCO.2016.71.9260. Epub 2017 May 17. PMID: 28514183; PMCID: PMC7186580.[2] Karam R, Conner B, LaDuca H, McGoldrick K, Krempely K, Richardson ME, Zimmermann H, Gutierrez S, Reineke P, Hoang L, Allen K, Yussuf A, Farber-Katz S, Rana HQ, Culver S, Lee J, Nashed S, Toppmeyer D, Collins D, Haynes G, Pesaran T, Dolinsky JS, Tippin Davis B, Elliott A, Chao E. Assessment of Diagnostic Outcomes of RNA Genetic Testing for Hereditary Cancer. JAMA Netw Open. 2019 Oct 2;2(10):e1913900. doi: 10.1001/jamanetworkopen.2019.13900. PMID: 31642931; PMCID: PMC6820040.Become a supporter of this podcast: https://www.spreaker.com/podcast/the-onco-zine-brief--2786156/support.

Episode Description

After checking your cholesterol, hemoglobin A1C, and glucose level during your annual wellness check, your primary care phycisian says: 'It looks like we haven't done your genome. Why don't we do that?' How would you respond? If you have a genetic mutation that increases your risk for a treatable medical condition, would you want to know? For many people the answer is yes. But typically, such information has not been a part of routine primary care.

In this episode Peter Hofland PhD talks with Noelle Carbognin and Elizabeth Chao, MD, FACMG, a Medical Geneticist at UC Irvine about about Lynch Syndrome, a type of inherited cancer syndrome associated with a genetic predisposition to different cancer types, including Colorectal cancer and about various aspects of genetic testing, new technologies, including next generation sequencing technology, and the potential future possibilities and benefits of genetic testing in preventing disease.[1][2]

About The Onco'Zine Brief
The Onco'Zine Brief is distributed in the United States via PRX (Public Radio Exchange). In the United Kingdom and Europe, the program is distributed via UK Health Radio (UKHR). And the program can be downloaded via most podcasts and streaming media services, including iTunes, Spotify, TuneIn, and iHeart Radio.

For more information about The Onco'Zine Brief or how to sponsor or support this public radio broadcast and podcast, visit: http://www.oncozine.com to download our Media Kit or visit Patreon at https://www.patreon.com/theoncozinebrief to support the program.

For more information about cancer and cancer treatments, visit our online journal Onco'Zine at www.oncozine.com

To sign up for The Onco'Zine Newsletter (open for residents of the United States only), text the word CANCER to 66866.

Reference
[1] Espenschied CR, LaDuca H, Li S, McFarland R, Gau CL, Hampel H. Multigene Panel Testing Provides a New Perspective on Lynch Syndrome. J Clin Oncol. 2017 Aug 1;35(22):2568-2575. doi: 10.1200/JCO.2016.71.9260. Epub 2017 May 17. PMID: 28514183; PMCID: PMC7186580.
[2] Karam R, Conner B, LaDuca H, McGoldrick K, Krempely K, Richardson ME, Zimmermann H, Gutierrez S, Reineke P, Hoang L, Allen K, Yussuf A, Farber-Katz S, Rana HQ, Culver S, Lee J, Nashed S, Toppmeyer D, Collins D, Haynes G, Pesaran T, Dolinsky JS, Tippin Davis B, Elliott A, Chao E. Assessment of Diagnostic Outcomes of RNA Genetic Testing for Hereditary Cancer. JAMA Netw Open. 2019 Oct 2;2(10):e1913900. doi: 10.1001/jamanetworkopen.2019.13900. PMID: 31642931; PMCID: PMC6820040.

Become a supporter of this podcast: https://www.spreaker.com/podcast/the-onco-zine-brief--2786156/support.