Managing Toxicities of Colorectal Cancer Drugs / Systemic Therapy – Dr. Rona Yaeger

Welcome to the third episode of our three-part series on colorectal cancer! In this episode of the Oncology Brothers we are joined by Dr. Rona Yaeger, a medical oncologist from the Memorial Sloan Kettering Cancer Center. Together, we dived into the management of common side effects associated with systemic treatments for colorectal cancer.   Episode Highlights: • Overview of 5-FU and capecitabine, including the importance of DPYD mutation testing and side effects like cytopenia, mucositis, and cardiac toxicity. • Discussion on the use of 5-FU bolus in both metastatic and adjuvant settings. • Insights into managing oxaliplatin-induced neuropathy and the potential benefits of oral cryotherapy. • Clinical pearls for irinotecan, including the management of diarrhea and cholinergic effects. • Considerations for using Bevacizumab, including risks of hypertension, proteinuria, and blood clots. • Tips for managing side effects of anti-EGFR agents like Cetuximab and Panitumumab, including rash and infusion reactions. • An overview of oral agents such as encorafenib, TAS-102, and Regorafenib, with a focus on dosing strategies and side effect management.   Join us as we explore these critical topics and provide valuable insights for healthcare professionals managing colorectal cancer treatments.   Listen us on: Spotify: https://open.spotify.com/show/31BXhY9FM4gPWG10WgE11o  Follow us on social media: X/Twitter: https://twitter.com/oncbrothers  ⁠Instagram: https://www.instagram.com/oncbrothers  Website: https://oncbrothers.com/    Don't forget to subscribe for more episodes! #ColorectalCancer, #SideEffectManagement, #DPYDtesting, #ChemotherapyToxicity, #SupportiveCare