Manipulating Host Cell Metabolism | Francisella tularensis Exploits Dendritic Cells to Drive Inflammation and Disease

In this episode of SciBud, join Rowan as we delve into a groundbreaking study that uncovers the intricate interplay between the intracellular bacterium Francisella tularensis and our immune system. Known for causing tularemia, this cunning pathogen hijacks dendritic cells, crucial players in our immune response, to enhance its spread and severity of infection. Discover how Francisella alters mitochondrial metabolism, specifically by prioritizing glutamate, to produce reactive oxygen species that inadvertently trigger harmful inflammation instead of battling the bacteria. Armed with advanced bioimaging techniques, researchers highlight the potential for new therapies targeting host metabolism to mitigate severe infections. Tune in as we explore the delicate balance between combating disease and the collateral damage that can occur, igniting curiosity about the future of infectious disease treatment. Link to episode page with article citation: www.scibud.media/podcast/season/2025/episode/145